Isabel V L Wilkinson
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Explore the profile of Isabel V L Wilkinson including associated specialties, affiliations and a list of published articles.
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11
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59
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Recent Articles
1.
Wilkinson I, Castro-Falcon G, Roda-Serrat M, Purdy T, Straetener J, Brauny M, et al.
Chembiochem
. 2022 Dec;
24(5):e202200455.
PMID: 36538283
The blue biliprotein phycocyanin, produced by photo-autotrophic cyanobacteria including spirulina (Arthrospira) and marketed as a natural food supplement or "nutraceutical," is reported to have anti-inflammatory, antioxidant, immunomodulatory, and anticancer activity....
2.
Wilkinson I, Bottlinger M, El Harraoui Y, Sieber S
Angew Chem Int Ed Engl
. 2022 Dec;
62(9):e202212111.
PMID: 36495310
Heme is a cofactor with myriad roles and essential to almost all living organisms. Beyond classical gas transport and catalytic functions, heme is increasingly appreciated as a tightly controlled signalling...
3.
Jackson T, Vuorinen A, Josa-Cullere L, Madden K, Conole D, Cogswell T, et al.
iScience
. 2022 Aug;
25(8):104787.
PMID: 35992086
Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify...
4.
Wilkinson I, Pfanzelt M, Sieber S
Angew Chem Int Ed Engl
. 2022 Mar;
61(29):e202201136.
PMID: 35286003
Cofactors are required for almost half of all enzyme reactions, but their functions and binding partners are not fully understood even after decades of research. Functionalised cofactor mimics that bind...
5.
Vuorinen A, Wilkinson I, Chatzopoulou M, Edwards B, Squire S, Fairclough R, et al.
Eur J Med Chem
. 2021 Apr;
220:113431.
PMID: 33915371
Duchenne muscular dystrophy is a fatal disease with no cure, caused by lack of the cytoskeletal protein dystrophin. Upregulation of utrophin, a dystrophin paralogue, offers a potential therapy independent of...
6.
Quevedo C, Bataille C, Byrne S, Durbin M, Elkins J, Guillermo A, et al.
Bioorg Med Chem
. 2020 Oct;
28(22):115724.
PMID: 33128909
We have previously reported the discovery of a series of rhodanine-based inhibitors of the PIM family of serine/threonine kinases. Here we described the optimisation of those compounds to improve their...
7.
Wilkinson I, Terstappen G, Russell A
Drug Discov Today
. 2020 Sep;
PMID: 32971235
Investment in phenotypic drug discovery has led to increased demand for rapid and robust target deconvolution to aid successful drug development. Although methods for target identification and mechanism of action...
8.
Babbs A, Chatzopoulou M, Edwards B, Squire S, Wilkinson I, Wynne G, et al.
Biochem Soc Trans
. 2020 Jun;
48(3):813-821.
PMID: 32597486
Genetic approaches for the diagnosis and treatment of inherited muscle diseases have advanced rapidly in recent years. Many of the advances have occurred in the treatment of Duchenne muscular dystrophy...
9.
Wilkinson I, Perkins K, Dugdale H, Moir L, Vuorinen A, Chatzopoulou M, et al.
Angew Chem Int Ed Engl
. 2019 Nov;
59(6):2420-2428.
PMID: 31755636
Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disease arising from mutations in the dystrophin gene. Upregulation of utrophin to compensate for the missing dystrophin offers a potential therapy independent...
10.
Wilkinson I, Reynolds J, Galan S, Vuorinen A, Sills A, Pires E, et al.
Bioorg Chem
. 2019 Nov;
94:103395.
PMID: 31733898
Firefly luciferase (FLuc) is a powerful tool for molecular and cellular biology, and popular in high-throughput screening and drug discovery. However, FLuc assays have been plagued with positive and negative...