Stephan A Sieber
Overview
Explore the profile of Stephan A Sieber including associated specialties, affiliations and a list of published articles.
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192
Citations
2670
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Recent Articles
1.
Duman E, Muller-Deubert S, Pattappa G, Stratos I, Sieber S, Clausen-Schaumann H, et al.
Pharmaceuticals (Basel)
. 2025 Feb;
18(2).
PMID: 40005998
The fluoroquinolone (FQ) class of antibiotics includes the world's most prescribed antibiotics such as ciprofloxacin, levofloxacin, and ofloxacin that are known for their low bacterial resistance. This is despite their...
2.
Schuh M, Boldini D, Bohne A, Sieber S
J Cheminform
. 2025 Feb;
17(1):18.
PMID: 39910404
Accurate prediction of drug-target interactions is critical for advancing drug discovery. By reducing time and cost, machine learning and deep learning can accelerate this laborious discovery process. In a novel...
3.
Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhauser D, et al.
NPJ Antimicrob Resist
. 2025 Jan;
2(1):33.
PMID: 39843645
Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent...
4.
Diamanti E, Steinbach A, de Carvalho L, Ropponen H, Lacour A, Hamid R, et al.
ACS Omega
. 2024 Nov;
9(44):44465-44473.
PMID: 39524657
The enzyme IspE in is considered an attractive drug target, as it is essential for parasite survival and is absent in the human proteome. Yet it still has not been...
5.
Hesse J, Boldini D, Sieber S
J Chem Inf Model
. 2024 Oct;
64(21):8142-8152.
PMID: 39440790
In the rapidly evolving field of drug discovery, high-throughput screening (HTS) is essential for identifying bioactive compounds. This study introduces a novel application of data valuation, a concept for evaluating...
6.
Schum D, Elsen F, Ruddell S, Schorpp K, Junca H, Musken M, et al.
JACS Au
. 2024 Aug;
4(8):3125-3134.
PMID: 39211621
Screening large molecule libraries against pathogenic bacteria is often challenged by a low hit rate due to limited uptake, underrepresentation of antibiotic structural motifs, and assays that do not resemble...
7.
Scharnow A, Solinski A, Rowe S, Drechsel I, Zhang H, Shaw E, et al.
J Am Chem Soc
. 2024 Aug;
146(33):23449-23456.
PMID: 39133525
Natural products are important precursors for antibiotic drug design. These chemical scaffolds serve as synthetic inspiration for chemists who leverage their structures to develop novel antibacterials and chemical probes. We...
8.
Geissler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, et al.
Chem Sci
. 2024 Aug;
15(30):11946-11955.
PMID: 39092115
Isonitrile natural products, also known as isocyanides, demonstrate potent antimicrobial activities, yet our understanding of their molecular targets remains limited. Here, we focus on the so far neglected group of...
9.
Gronauer T, Eck L, Ludwig C, Sieber S
Angew Chem Int Ed Engl
. 2024 Jul;
63(46):e202409220.
PMID: 39073273
Protein homeostasis in bacteria is regulated by proteases such as the tetradecameric caseinolytic protease P (ClpP). Although substrates of ClpP have been successfully deciphered in genetically engineered cells, methods which...
10.
Chen S, Fiedler M, Gronauer T, Omelko O, von Wrisberg M, Wang T, et al.
Commun Biol
. 2024 Jul;
7(1):895.
PMID: 39043865
Staphylococcus aureus signal peptidase IB (SpsB) is an essential enzyme for protein secretion. While inhibition of its activity by small molecules is a well-precedented mechanism to kill bacteria, the mode...