Isabel R Schlaepfer
Overview
Explore the profile of Isabel R Schlaepfer including associated specialties, affiliations and a list of published articles.
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34
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1240
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Recent Articles
1.
Potcoava M, Futia G, Gibson E, Schlaepfer I
J Raman Spectrosc
. 2022 Jul;
52(11):1910-1922.
PMID: 35814195
Lipid droplets are dynamic organelles that play important cellular roles. They are composed of a phospholipid membrane and a core of triglycerides and sterol esters. Fatty acids have important roles...
2.
Turner J, Paton E, Van Gulick R, Stefanoni D, Cendali F, Reisz J, et al.
Cancers (Basel)
. 2022 May;
14(9).
PMID: 35565240
There is increasing evidence that oxidative metabolism and fatty acids play an important role in BRAF-driven tumorigenesis, yet the effect of mutation and expression on metabolism is poorly understood. We...
3.
Cernera G, Di Donato M, Higgins P, Schlaepfer I
Front Cell Dev Biol
. 2022 May;
10:887529.
PMID: 35493105
No abstract available.
4.
Potcoava M, Futia G, Gibson E, Schlaepfer I
Methods Mol Biol
. 2022 Jan;
2413:193-209.
PMID: 35044667
Raman spectroscopy using feature selection schemes has considerable advantages over gas chromatography for the analysis of fatty acids' composition changes. Here, we introduce an educational methodology to demonstrate the potential...
5.
Rios-Colon L, Kumar P, Kim S, Sharma M, Su Y, Kumar A, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34944922
Hypoxia and hypoxia-related biomarkers are the major determinants of prostate cancer (PCa) aggressiveness. Therefore, a better understanding of molecular players involved in PCa cell survival under hypoxia could offer novel...
6.
Kim K, Oh K, Shim J, Schlaepfer I, Karam S, Lee J
Polymers (Basel)
. 2021 Feb;
13(3).
PMID: 33530388
Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a...
7.
Guth A, Monk E, Agarwal R, Bergman B, Zemski-Berry K, Minic A, et al.
Int J Mol Sci
. 2020 Dec;
21(24).
PMID: 33352903
Lipid catabolism represents an Achilles heel in prostate cancer (PCa) that can be exploited for therapy. CPT1A regulates the entry of fatty acids into the mitochondria for beta-oxidation and its...
8.
Joshi M, Kim J, DAlessandro A, Monk E, Bruce K, Elajaili H, et al.
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33218188
Cancers reprogram their metabolism to adapt to environmental changes. In this study, we examined the consequences of altered expression of the mitochondrial enzyme carnitine palmitoyl transferase I (CPT1A) in prostate...
9.
Paton E, Turner J, Schlaepfer I
J Oncol
. 2020 May;
2020:1079827.
PMID: 32411231
Overactivation of the mitogen-activated protein kinase (MAPK) pathway is an important driver of many human cancers. First line, FDA-approved therapies targeting MAPK signalling, which include BRAF and MEK inhibitors, have...
10.
Sawyer B, Qamar L, Yamamoto T, McMellen A, Watson Z, Richer J, et al.
Mol Cancer Res
. 2020 Mar;
18(7):1088-1098.
PMID: 32198139
Epithelial-derived high-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic malignancy. Roughly 80% of patients are diagnosed with late-stage disease, which is defined by wide-spread cancer dissemination throughout the pelvic...