Iris Eke
Overview
Explore the profile of Iris Eke including associated specialties, affiliations and a list of published articles.
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Articles
50
Citations
1276
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Recent Articles
1.
Bylicky M, Shankavaram U, Aryankalayil M, Chopra S, Naz S, Sowers A, et al.
Mol Cancer Ther
. 2024 Feb;
23(4):577-588.
PMID: 38359816
Treatments involving radiation and chemotherapy alone or in combination have improved patient survival and quality of life. However, cancers frequently evade these therapies due to adaptation and tumor evolution. Given...
2.
Aryankalayil M, Bylicky M, Martello S, Chopra S, Sproull M, May J, et al.
Int J Radiat Biol
. 2023 May;
99(11):1702-1715.
PMID: 37212632
Purpose: Previous research has highlighted the impact of radiation damage, with cancer patients developing acute disorders including radiation induced pneumonitis or chronic disorders including pulmonary fibrosis months after radiation therapy...
3.
Eke I, Guo H, Loo Jr B, Sung A, Diehn M, Vitzthum L, et al.
Pract Radiat Oncol
. 2023 May;
13(5):e383-e388.
PMID: 37150318
We present the case of a woman with metastatic adenoid cystic carcinoma who received stereotactic ablative radiation therapy with a total dose of 50 Gy in 4 fractions to 2...
4.
Eke I, Aryankalayil M, Bylicky M, Makinde A, Liotta L, Calvert V, et al.
Sci Rep
. 2022 Mar;
12(1):3500.
PMID: 35241721
The efficacy of molecular targeted therapy depends on expression and enzymatic activity of the target molecules. As radiotherapy modulates gene expression and protein phosphorylation dependent on dose and fractionation, we...
5.
Eke I, Aryankalayil M, Bylicky M, Sandfort V, Vanpouille-Box C, Nandagopal S, et al.
Cancer Immunol Immunother
. 2021 Aug;
71(4):839-850.
PMID: 34435232
The expression of immune-related genes in cancer cells can alter the anti-tumor immune response and thereby impact patient outcomes. Radiotherapy has been shown to modulate immune-related genes dependent on the...
6.
Aryankalayil M, Martello S, Bylicky M, Chopra S, May J, Shankardass A, et al.
J Transl Med
. 2021 Aug;
19(1):336.
PMID: 34364390
Background: Radiation therapy is integral to effective thoracic cancer treatments, but its application is limited by sensitivity of critical organs such as the heart. The impacts of acute radiation-induced damage...
7.
Eke I, Bylicky M, Sandfort V, Chopra S, Martello S, Graves E, et al.
Mol Ther Nucleic Acids
. 2021 Mar;
24:175-187.
PMID: 33767914
Long non-coding RNAs (lncRNAs) have been shown to impact important biological functions such as proliferation, survival, and genomic stability. To analyze radiation-induced lncRNA expression in human tumors, we irradiated prostate...
8.
Coleman C, Eke I, Makinde A, Chopra S, Demaria S, Formenti S, et al.
Clin Cancer Res
. 2020 Jun;
26(22):5781-5790.
PMID: 32554542
Radiotherapy is highly effective due to its ability to physically focus the treatment to target the tumor while sparing normal tissue and its ability to be combined with systemic therapy....
9.
Eke I, Zong D, Aryankalayil M, Sandfort V, Bylicky M, Rath B, et al.
Nucleic Acids Res
. 2019 Dec;
48(3):1314-1326.
PMID: 31822909
Multifractionated irradiation is the mainstay of radiation treatment in cancer therapy. Yet, little is known about the cellular DNA repair processes that take place between radiation fractions, even though understanding...
10.
Eke I, Makinde A, Aryankalayil M, Reedy J, Citrin D, Chopra S, et al.
Mol Cancer Res
. 2018 Jul;
16(12):1855-1864.
PMID: 30042176
Adaptation of tumor cells to radiotherapy induces changes that are actionable by molecular targeted agents and immunotherapy. This report demonstrates that radiation-induced changes in integrin expression can be targeted 2...