Ira Fleming
Overview
Explore the profile of Ira Fleming including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
13
Citations
160
Followers
0
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Recent Articles
1.
Tamburini B, Sheridan R, Doan T, Lucas C, Forward T, Fleming I, et al.
Res Sq
. 2024 Dec;
PMID: 39711554
Lymph node (LN) lymphatic endothelial cells (LEC) actively acquire and archive foreign antigens. Here, we address questions of how LECs achieve durable antigen archiving and whether LECs with high levels...
2.
Doan T, Forward T, Schafer J, Lucas E, Fleming I, Uecker-Martin A, et al.
NPJ Vaccines
. 2024 Mar;
9(1):66.
PMID: 38514656
Antigens from viruses or immunizations can persist or are archived in lymph node stromal cells such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here, we find that,...
3.
Wilk A, Marceau J, Kazer S, Fleming I, Miao V, Galvez-Reyes J, et al.
Genome Med
. 2024 Feb;
16(1):24.
PMID: 38317183
Background: The Lentivirus human immunodeficiency virus (HIV) causes chronic inflammation and AIDS in humans, with variable rates of disease progression between individuals driven by both host and viral factors. Similarly,...
4.
Lee H, Zhao Y, Fleming I, Mehta S, Wang X, Vander Wyk B, et al.
iScience
. 2023 Dec;
26(12):108387.
PMID: 38047068
Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures...
5.
Tamburini B, Doan T, Forward T, Lucas E, Fleming I, Uecker-Martin A, et al.
Res Sq
. 2023 Oct;
PMID: 37841845
Viral and vaccine antigens persist or are archived in lymph node stromal cells (LNSC) such as lymphatic endothelial cells (LEC) and fibroblastic reticular cells (FRC). Here, we find that, during...
6.
Genshaft A, Subudhi S, Keo A, Vasquez J, Conceicao-Neto N, Mahamed D, et al.
Hepatology
. 2023 May;
78(5):1525-1541.
PMID: 37158243
Background And Aims: HBV infection is restricted to the liver, where it drives exhaustion of virus-specific T and B cells and pathogenesis through dysregulation of intrahepatic immunity. Our understanding of...
7.
Kummerlowe C, Mwakamui S, Hughes T, Mulugeta N, Mudenda V, Besa E, et al.
Sci Transl Med
. 2022 Aug;
14(660):eabi8633.
PMID: 36044598
Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly prevalent in low- and middle-income countries. It is thought to be a key contributing factor to...
8.
Lemos M, Nandi V, Dragavon J, Fleming I, Krishnan K, Musuruana M, et al.
J Acquir Immune Defic Syndr
. 2021 Sep;
88(2):138-148.
PMID: 34506358
Background: To focus interventions, biomarkers of HIV-1 exposure could help in identifying subpopulations at highest risk of acquisition. We assessed whether Y-chromosome single tandem repeat (YSTR) mixtures obtained from rectal...
9.
Jiang R, Meng H, Raddassi K, Fleming I, Hoehn K, Dardick K, et al.
JCI Insight
. 2021 Jun;
6(12).
PMID: 34061047
The skin lesion erythema migrans (EM) is an initial sign of the Ixodes tick-transmitted Borreliella spirochetal infection known as Lyme disease. T cells and innate immune cells have previously been...
10.
Goods B, Askenase M, Markarian E, Beatty H, Drake R, Fleming I, et al.
JCI Insight
. 2021 Mar;
6(6).
PMID: 33749664
Intracerebral hemorrhage (ICH) is a devastating form of stroke with a high mortality rate and few treatment options. Discovery of therapeutic interventions has been slow given the challenges associated with...