Ippei Takashima
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Explore the profile of Ippei Takashima including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
86
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Recent Articles
1.
Okuda K, Takagi A, Shimizu R, Nishi K, Hayano N, Takasihma I, et al.
ChemMedChem
. 2025 Jan;
:e202400818.
PMID: 39812162
The antiausterity strategy in anticancer drug discovery has attracted much attention as a way to exterminate cancer cells under nutrient deprived conditions which are commonly found in solid tumors. These...
2.
Takagi A, Takashima I, Okuda K
RSC Adv
. 2025 Jan;
15(1):428-434.
PMID: 39758904
Fluorogenic probes containing the β-ketoester structure were developed for selective hydrazine detection. The probe equipped with a cyclopropane moiety, having reduced steric hindrance, showed a higher reaction rate than its...
3.
Takagi A, Usuguchi K, Takashima I, Okuda K
Chem Pharm Bull (Tokyo)
. 2023 Aug;
71(8):641-649.
PMID: 37532534
One aspect of cancer-specific environments, nutrient starvation, is a factor in cancer cell resistance to treatment with chemotherapeutic agents and development of malignancy. Our newly synthesized novel glucose derivative β-1,3,6-O-tribenzoyl-D-glucose...
4.
Okuda K, Takashima I, Takagi A
J Clin Biochem Nutr
. 2023 Feb;
72(1):1-12.
PMID: 36777081
Recently, the behavior of essential trace metal elements in living organisms has attracted more and more attention as their dynamics have been found to be tightly regulated by metallothionines, transporters,...
5.
Kanegae A, Takata Y, Takashima I, Uchinomiya S, Kawagoe R, Usui K, et al.
Commun Chem
. 2023 Jan;
4(1):104.
PMID: 36697807
Despite continuous and active development of fluorescent metal-ion probes, their molecular design for ratiometric detection is restricted by the limited choice of available sensing mechanisms. Here we present a multicolor...
6.
Takagi A, Usuguchi K, Takashima I, Okuda K
Org Lett
. 2021 Feb;
23(11):4083-4087.
PMID: 33596082
The antiausterity natural product (±)-uvaridacol L was synthesized for the first time in seven steps from -inositol. The key reaction of this synthesis, axial selective dibenzoylation of -inositol orthoformate, was...
7.
Hakariya H, Takashima I, Takemoto M, Noda N, Sato S, Uesugi M
Chem Commun (Camb)
. 2021 Jan;
57(12):1470-1473.
PMID: 33442714
This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to...
8.
Takashima I, Inoue Y, Matsumoto N, Takagi A, Okuda K
Chem Commun (Camb)
. 2020 Oct;
56(87):13327-13330.
PMID: 33063059
Labile zinc plays various roles in cells at low concentrations which most fluorescent probes are not able to detect. Here we report a cephem-based probe which coordinates to zinc and...
9.
Jin S, Vu H, Hioki K, Noda N, Yoshida H, Shimane T, et al.
Angew Chem Int Ed Engl
. 2020 Sep;
60(2):961-969.
PMID: 32979004
Immune potentiators, termed adjuvants, trigger early innate immune responses to ensure the generation of robust and long-lasting adaptive immune responses of vaccines. Presented here is a study that takes advantage...
10.
Takashima I, Kusamori K, Hakariya H, Takashima M, Vu T, Mizukami Y, et al.
ACS Chem Biol
. 2019 Feb;
14(4):775-783.
PMID: 30807095
Cell-based therapy is a promising approach to restoring lost functions to compromised organs. However, the issue of inefficient cell engraftment remains to be resolved. Herein, we take a chemical approach...