Shin-Ichi Sato
Overview
Explore the profile of Shin-Ichi Sato including associated specialties, affiliations and a list of published articles.
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Articles
60
Citations
589
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Recent Articles
1.
Takemoto M, Delghandi S, Abo M, Yurimoto K, Odagi M, Singh V, et al.
J Am Chem Soc
. 2025 Jan;
147(3):2902-2912.
PMID: 39794153
Despite the unprecedented therapeutic potential of immune checkpoint antibody therapies, their efficacy is limited partly by the dysfunction of T cells within the cancer microenvironment. Combination therapies with small molecules...
2.
Yatsuzuka K, Katsuda Y, Sato S
Methods Mol Biol
. 2024 Nov;
2875:189-204.
PMID: 39535650
Imaging of RNA dynamics in living cells is increasingly important to understanding and measuring spatially restricted gene expression. We recently developed a live-cell RNA imaging method that combines an RNA...
3.
Singh V, Hirose S, Takemoto M, Farrag A, Sato S, Honjo T, et al.
J Am Chem Soc
. 2024 Jun;
PMID: 38848460
Cancer immune therapies, particularly programmed cell death protein 1 (PD-1) blockade immunotherapy, falter in aged individuals due to compromised T-cell immunity. Spermidine, a biogenic polyamine that declines along with aging,...
4.
Toh K, Nishio K, Nakagawa R, Egoshi S, Abo M, Perron A, et al.
J Am Chem Soc
. 2022 Oct;
144(44):20171-20176.
PMID: 36306265
Visible light, particularly in the blue region of the spectrum, can cause cell dysfunction through the generation of singlet oxygen, contributing to cellular aging and age-related pathologies. Although photooxidation of...
5.
Katsuda Y, Sato S, Inoue M, Tsugawa H, Kamura T, Kida T, et al.
Nucleic Acids Res
. 2022 Jul;
50(14):8143-8153.
PMID: 35801908
Tandem repeats of guanine-rich sequences in RNA often form thermodynamically stable four-stranded RNA structures. Such RNA G-quadruplexes have long been considered to be linked to essential biological processes, yet their...
6.
Ado G, Noda N, Vu H, Perron A, Mahapatra A, Arista K, et al.
Chem Sci
. 2022 Jun;
13(19):5760-5766.
PMID: 35694339
Phase-separated membraneless organelles or biomolecular condensates play diverse functions in cells, however recapturing their characteristics using small organic molecules has been a challenge. In the present study, cell-lysate-based screening of...
7.
Noda N, Jung Y, Ado G, Mizuhata Y, Higuchi M, Ogawa T, et al.
ACS Chem Biol
. 2022 Feb;
17(3):567-575.
PMID: 35188733
The present study reports a surprising protein-condensing effect of glucose, prompted by our accidental observation during chemical library screening under a high-glucose condition. We noticed "glucosing-out" of certain compounds, in...
8.
Jung Y, Noda N, Takaya J, Abo M, Toh K, Tajiri K, et al.
ACS Chem Biol
. 2022 Jan;
17(2):340-347.
PMID: 35076225
Covalent inhibitors of enzymes are increasingly appreciated as pharmaceutical seeds, yet discovering non-cysteine-targeting inhibitors remains challenging. Herein, we report an intriguing experience during our activity-based proteomic screening of 1601 reactive...
9.
Pe K, Yatsuzuka K, Hakariya H, Kida T, Katsuda Y, Fukuda M, et al.
Nucleic Acids Res
. 2021 Sep;
49(22):e132.
PMID: 34581825
Imaging the dynamics of proteins in living cells is a powerful means for understanding cellular functions at a deeper level. Here, we report a versatile method for spatiotemporal imaging of...
10.
Fujiwara T, Sato M, Sato S, Fukuoka T
J Otol
. 2021 Jul;
16(3):144-149.
PMID: 34220983
Background: Patients undergoing intensive care are exposed to risk factors for hearing impairment. This study assessed the worse changes in pure tone average (PTA) thresholds after intensive care and identified...