Itaru Hamachi
Overview
Explore the profile of Itaru Hamachi including associated specialties, affiliations and a list of published articles.
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Articles
213
Citations
2933
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Recent Articles
1.
Zhu H, Uno H, Matsuba K, Hamachi I
J Am Chem Soc
. 2025 Feb;
147(9):7305-7316.
PMID: 39988859
Peroxynitrite (ONOO), the product of the diffusion-controlled reaction of superoxide (O) with nitric oxide (NO), plays a crucial role in oxidative and nitrative stress and modulates key physiological processes such...
2.
Ueda Y, Kiyonaka S, Selfors L, Inoue K, Harada H, Doura T, et al.
Nat Cell Biol
. 2025 Feb;
27(3):530-543.
PMID: 39984655
Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive. Here,...
3.
Yamaura K, Takemata N, Kariya M, Osaka A, Ishino S, Yamauchi M, et al.
Nat Commun
. 2025 Feb;
16(1):1312.
PMID: 39971902
In eukaryotes, structural maintenance of chromosomes (SMC) complexes form topologically associating domains (TADs) by extruding DNA loops and being stalled by roadblock proteins. It remains unclear whether a similar mechanism...
4.
Zenmyo N, Matsumoto Y, Yasuda A, Uchinomiya S, Shindo N, Sasaki-Tabata K, et al.
J Am Chem Soc
. 2025 Jan;
147(4):3080-3091.
PMID: 39818953
Site-selective cleavage of the peptide backbone in proteins is an important class of post-translational modification (PTM) in nature. However, the organic chemistry for such site-selective peptide bond cleavages has yet...
5.
Tamura T, Kawano M, Hamachi I
Chem Rev
. 2025 Jan;
125(2):1191-1253.
PMID: 39772527
The term "undruggable" refers to proteins or other biological targets that have been historically challenging to target with conventional drugs or therapeutic strategies because of their structural, functional, or dynamic...
6.
Nishimura M, Kodera T, Adachi S, Sato A, Takeuchi R, Nonaka H, et al.
Neurosci Res
. 2024 Dec;
212:20-30.
PMID: 39724942
Despite the crucial role of synaptic connections and neural activity in the development and organization of cortical circuits, the mechanisms underlying the formation of functional synaptic connections in the developing...
7.
Alkhalaf L, Arrowsmith C, Balskus E, Bergamini G, Bhandari R, Chang C, et al.
Nat Chem Biol
. 2024 Dec;
21(1):6-15.
PMID: 39719500
No abstract available.
8.
Tamura T, Hamachi I
Methods Mol Biol
. 2024 Dec;
2888:1-11.
PMID: 39699720
Phosphatidylcholine (PC) is a major phospholipid that forms biological membranes in eukaryotes. PC is mainly synthesized in the endoplasmic reticulum (ER) and Golgi apparatus and then transported to other organelle...
9.
Tamura T, Hamachi I
Acc Chem Res
. 2024 Dec;
58(1):87-100.
PMID: 39661110
ConspectusSelective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology. Such modification has a variety of applications important for...
10.
Vaidya R, Zhang J, Nall D, Lee Y, Chang Kim E, Ma D, et al.
bioRxiv
. 2024 Aug;
PMID: 39091751
Synaptic AMPA receptors (AMPARs) on neuronal plasma membranes are correlated with learning and memory. Using a unique labeling and super-resolution imaging, we have visualized the nanoscale synaptic and extra-synaptic organization...