Motonari Uesugi
Overview
Explore the profile of Motonari Uesugi including associated specialties, affiliations and a list of published articles.
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109
Citations
1283
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Recent Articles
1.
Takemoto M, Delghandi S, Abo M, Yurimoto K, Odagi M, Singh V, et al.
J Am Chem Soc
. 2025 Jan;
147(3):2902-2912.
PMID: 39794153
Despite the unprecedented therapeutic potential of immune checkpoint antibody therapies, their efficacy is limited partly by the dysfunction of T cells within the cancer microenvironment. Combination therapies with small molecules...
2.
Etezadi F, Ito S, Yasui K, Kado Abdalkader R, Minami I, Uesugi M, et al.
J Chem Inf Model
. 2024 Nov;
64(23):8824-8837.
PMID: 39586080
The discovery of small organic compounds for inducing stem cell differentiation is a time- and resource-intensive process. While data science could, in principle, streamline the discovery of these compounds, novel...
3.
Singh V, Hirose S, Takemoto M, Farrag A, Sato S, Honjo T, et al.
J Am Chem Soc
. 2024 Jun;
PMID: 38848460
Cancer immune therapies, particularly programmed cell death protein 1 (PD-1) blockade immunotherapy, falter in aged individuals due to compromised T-cell immunity. Spermidine, a biogenic polyamine that declines along with aging,...
4.
Ochiai T, Inukai T, Akiyama M, Furui K, Ohue M, Matsumori N, et al.
Commun Chem
. 2023 Nov;
6(1):249.
PMID: 37973971
The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space...
5.
Kawagoe F, Mototani S, Mendoza A, Takemoto Y, Uesugi M, Kittaka A
RSC Med Chem
. 2023 Oct;
14(10):2030-2034.
PMID: 37859714
Vitamin D metabolites block lipid biosynthesis by promoting degradation of the complex of sterol regulatory element-binding protein (SREBP) and SREBP cleavage-activating protein (SCAP) independent of their effects on the vitamin...
6.
Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, et al.
J Am Chem Soc
. 2023 Oct;
145(46):25283-25292.
PMID: 37857329
DNA-encoded chemical library (DEL) has been extensively used for lead compound discovery for decades in academia and industry. Incorporating an electrophile warhead into DNA-encoded compounds recently permitted the discovery of...
7.
Perron A, Mandal S, Negrao Chuba T, Mao D, Singh V, Noda N, et al.
ACS Chem Biol
. 2023 Sep;
18(10):2170-2175.
PMID: 37708070
Despite the well-established role of oxidative stress in the pathogenesis of age-related macular degeneration (AMD), the mechanism underlying phototoxicity remains unclear. Herein, we used a drug repurposing approach to isolate...
8.
Zhuo S, Noda N, Hioki K, Jin S, Hayashi T, Hiraga K, et al.
J Med Chem
. 2023 Sep;
66(18):13266-13279.
PMID: 37676021
Protein or peptide cancer vaccines usually include immune potentiators, so-called adjuvants. However, it remains challenging to identify structurally simple, chemically accessible synthetic molecules that are effective and safe as vaccine...
9.
Tanaka K, Suda A, Uesugi M, Futaki S, Imanishi M
Chem Commun (Camb)
. 2023 Aug;
59(72):10809-10812.
PMID: 37599611
Xanthine derivatives were identified as inhibitors of the -methyladenosine (m6A) demethylase activity of fat-mass-and-obesity-associated protein (FTO) by activity-based high-throughput screening using the m6A-sensitive ribonuclease MazF. Pentoxifylline exhibited L-ascorbic acid concentration-dependent...
10.
Cutrupi A, Narayanan R, Perez-Siles G, Grosz B, Lai K, Boyling A, et al.
Brain
. 2022 Nov;
146(3):880-897.
PMID: 36380488
Distal hereditary motor neuropathies (dHMNs) are a group of inherited diseases involving the progressive, length-dependent axonal degeneration of the lower motor neurons. There are currently 29 reported causative genes and...