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Inna Ricardo-Lax

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Articles 18
Citations 519
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Recent Articles
1.
Khan M, Irvin P, Park S, Ivester H, Ricardo-Lax I, Leek M, et al.
JCI Insight . 2024 Dec; 10(1. PMID: 39625789
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a global pandemic pathogen with high mortality. While treatments have been developed to reduce...
2.
Tse A, Acreman C, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, et al.
PLoS Pathog . 2024 Nov; 20(11):e1012704. PMID: 39546542
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate...
3.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook A, Bauer M, et al.
PLoS Biol . 2024 Sep; 22(9):e3002767. PMID: 39316623
Interferons (IFNs) play a crucial role in the regulation and evolution of host-virus interactions. Here, we conducted a genome-wide arrayed CRISPR knockout screen in the presence and absence of IFN...
4.
Tse A, Acreman C, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, et al.
bioRxiv . 2024 Jul; PMID: 38979151
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate...
5.
Udi Y, Zhang W, Stein M, Ricardo-Lax I, Pasolli H, Chait B, et al.
J Cell Biol . 2023 Mar; 222(6). PMID: 36920247
Subcellular fractionation in combination with mass spectrometry-based proteomics is a powerful tool to study localization of key proteins in health and disease. Here we offered a reliable and rapid method...
6.
Kabbani M, Michailidis E, Steensels S, Fulmer C, Luna J, Le Pen J, et al.
Cell Rep . 2022 Sep; 40(11):111321. PMID: 36103835
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein...
7.
Broennimann K, Ricardo-Lax I, Adler J, Shaul Y
Cells . 2022 Jul; 11(14). PMID: 35883690
The hepatitis B virus (HBV) is one of the smallest but most highly infectious human pathogens. With a DNA genome of only 3.2 kb and only four genes, HBV successfully...
8.
Broennimann K, Ricardo-Lax I, Adler J, Michailidis E, de Jong Y, Reuven N, et al.
Biomolecules . 2021 Dec; 11(12). PMID: 34944466
DNA viruses require dNTPs for replication and have developed different strategies to increase intracellular dNTP pools. Hepatitis B virus (HBV) infects non-dividing cells in which dNTPs are scarce and the...
9.
Ricardo-Lax I, Luna J, Thao T, Le Pen J, Yu Y, Hoffmann H, et al.
Science . 2021 Oct; 374(6571):1099-1106. PMID: 34648371
Molecular virology tools are critical for basic studies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and for developing new therapeutics. Experimental systems that do not rely on viruses...
10.
Schneider W, Luna J, Hoffmann H, Sanchez-Rivera F, Leal A, Ashbrook A, et al.
Cell . 2020 Dec; 184(1):120-132.e14. PMID: 33382968
The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of over one million people worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of...