Ilona U Rafalska-Metcalf
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Explore the profile of Ilona U Rafalska-Metcalf including associated specialties, affiliations and a list of published articles.
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10
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629
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Recent Articles
1.
Morrell T, Rafalska-Metcalf I, Yang H, Chu J
J Am Chem Soc
. 2018 Oct;
140(44):14747-14752.
PMID: 30301350
Protein tyrosine phosphatase B (PtpB) from Mycobacterium tuberculosis (Mtb) extends the bacteria's survival in hosts and hence is a potential target for Mtb-specific drugs. To study how Mtb-specific sequence insertions...
2.
Emerson N, Hsia C, Rafalska-Metcalf I, Yang H
Nanoscale
. 2014 Mar;
6(9):4538-43.
PMID: 24664211
Nanotechnology has opened up the opportunity to probe, sense, and manipulate the chemical environment of biological systems with an unprecedented level of spatiotemporal control. A major obstacle to the full...
3.
Newhart A, Rafalska-Metcalf I, Yang T, Joo L, Powers S, Kossenkov A, et al.
J Biol Chem
. 2013 May;
288(27):19882-99.
PMID: 23689370
Unlike the core histones, which are incorporated into nucleosomes concomitant with DNA replication, histone H3.3 is synthesized throughout the cell cycle and utilized for replication-independent (RI) chromatin assembly. The RI...
4.
Newhart A, Negorev D, Rafalska-Metcalf I, Yang T, Maul G, Janicki S
Mol Biol Cell
. 2013 Mar;
24(9):1454-68.
PMID: 23485562
Promyelocytic leukemia nuclear bodies (PML-NBs)/nuclear domain 10s (ND10s) are nuclear structures that contain many transcriptional and chromatin regulatory factors. One of these, Sp100, is expressed from a single-copy gene and...
5.
Rafalska-Metcalf I, Janicki S
Methods Mol Biol
. 2013 Feb;
977:249-58.
PMID: 23436368
Imaging molecularly defined regions of chromatin in single living cells during transcriptional activation has the potential to provide new insight into gene regulatory mechanisms. Here, we describe a method for...
6.
Newhart A, Rafalska-Metcalf I, Yang T, Negorev D, Janicki S
J Cell Sci
. 2012 Sep;
125(Pt 22):5489-501.
PMID: 22976303
Histone H3.3 is a constitutively expressed H3 variant implicated in the epigenetic inheritance of chromatin structures. Recently, the PML-nuclear body (PML-NB)/Nuclear Domain 10 (ND10) proteins, Daxx and ATRX, were found...
7.
White D, Rafalska-Metcalf I, Ivanov A, Corsinotti A, Peng H, Lee S, et al.
Mol Cancer Res
. 2011 Dec;
10(3):401-14.
PMID: 22205726
The repair of DNA damage in highly compact, transcriptionally silent heterochromatin requires that repair and chromatin packaging machineries be tightly coupled and regulated. KAP1 is a heterochromatin protein and co-repressor...
8.
Shanbhag N, Rafalska-Metcalf I, Balane-Bolivar C, Janicki S, Greenberg R
Cell
. 2010 Jun;
141(6):970-81.
PMID: 20550933
DNA double-strand breaks (DSBs) initiate extensive local and global alterations in chromatin structure, many of which depend on the ATM kinase. Histone H2A ubiquitylation (uH2A) on chromatin surrounding DSBs is...
9.
Rafalska-Metcalf I, Powers S, Joo L, LeRoy G, Janicki S
PLoS One
. 2010 Apr;
5(4):e10272.
PMID: 20422051
Background: Gene activation is thought to occur through a series of temporally defined regulatory steps. However, this process has not been completely evaluated in single living mammalian cells. Methodology/principal Findings:...
10.
Rafalska-Metcalf I, Janicki S
J Cell Sci
. 2007 Jul;
120(Pt 14):2301-7.
PMID: 17606985
The development of non-invasive methods of visualizing proteins and nucleic acids in living cells has provided profound insight into how they move and interact with each other in vivo. It...