Roger A Greenberg
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Explore the profile of Roger A Greenberg including associated specialties, affiliations and a list of published articles.
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97
Citations
6998
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Recent Articles
1.
Li F, Zhang T, Syed A, Elbakry A, Holmer N, Nguyen H, et al.
Nat Commun
. 2025 Feb;
16(1):1714.
PMID: 39962076
The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome...
2.
OSullivan R, Greenberg R
Cold Spring Harb Perspect Biol
. 2024 Nov;
17(1.
PMID: 39500623
In recent years, significant advances have been made in understanding the intricate details of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a specialized DNA strand break repair...
3.
Kim S, Greenberg R
Mol Cell
. 2024 Oct;
84(20):3868-3870.
PMID: 39423795
In a recent study in Cell, Lascaux et al. implicate TEX264 in the autophagy-driven resolution of nuclear topoisomerase 1 cleavage complexes (TOP1cc) in lysosomes, altering current concepts on the mechanism...
4.
Chandler F, Reddy P, Bhutda S, Ross R, Datta A, Walden M, et al.
bioRxiv
. 2024 Sep;
PMID: 39282282
Deubiquitylases (DUBs) are crucial in cell signalling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by cleaving K63-linked polyubiquitin chains on...
5.
Grothusen G, Chang R, Cao Z, Zhou N, Mittal M, Datta A, et al.
Nat Commun
. 2024 Jul;
15(1):5604.
PMID: 38961054
The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown. Using...
6.
Chauvin S, Ando S, Holley J, Sugie A, Zhao F, Poddar S, et al.
Nat Commun
. 2024 Jun;
15(1):4696.
PMID: 38824133
Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic...
7.
Jiang H, Zhang T, Kaur H, Shi T, Krishnan A, Kwon Y, et al.
Mol Cell
. 2024 Apr;
84(9):1684-1698.e9.
PMID: 38593805
The Bloom syndrome (BLM) helicase is critical for alternative lengthening of telomeres (ALT), a homology-directed repair (HDR)-mediated telomere maintenance mechanism that is prevalent in cancers of mesenchymal origin. The DNA...
8.
Krishnamoorthy V, Foglizzo M, Dilley R, Wu A, Datta A, Dutta P, et al.
Cell
. 2024 Mar;
187(9):2250-2268.e31.
PMID: 38554706
Ubiquitin-dependent unfolding of the CMG helicase by VCP/p97 is required to terminate DNA replication. Other replisome components are not processed in the same fashion, suggesting that additional mechanisms underlie replication...
9.
Zhang T, Rawal Y, Jiang H, Kwon Y, Sung P, Greenberg R
Nature
. 2023 Jun;
619(7968):201-208.
PMID: 37316655
Break-induced telomere synthesis (BITS) is a RAD51-independent form of break-induced replication that contributes to alternative lengthening of telomeres. This homology-directed repair mechanism utilizes a minimal replisome comprising proliferating cell nuclear...
10.
Ciccia A, Greenberg R, Lees-Miller S, Nussenzweig A
Fac Rev
. 2022 Dec;
11:35.
PMID: 36532708
To maintain genome fidelity and prevent diseases such as cancer, our cells must constantly detect, and efficiently and precisely repair, DNA damage. Paradoxically, DNA-damaging agents in the form of radiation...