Ilana Keshet
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Explore the profile of Ilana Keshet including associated specialties, affiliations and a list of published articles.
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11
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1194
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Recent Articles
1.
Greenfield R, Tabib A, Keshet I, Moss J, Sabag O, Goren A, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):10387-10391.
PMID: 30257947
Following erasure in the blastocyst, the entire genome undergoes de novo methylation at the time of implantation, with CpG islands being protected from this process. This bimodal pattern is then...
2.
Hecht M, Tabib A, Kahan T, Orlanski S, Gropp M, Tabach Y, et al.
Int J Dev Biol
. 2017 Jun;
61(3-4-5):285-292.
PMID: 28621425
Fragile X syndrome is the most frequent cause of inherited intellectual disability. The primary molecular defect in this disease is the expansion of a CGG repeat in the 5' region...
3.
Reizel Y, Spiro A, Sabag O, Skversky Y, Hecht M, Keshet I, et al.
Genes Dev
. 2015 May;
29(9):923-33.
PMID: 25934504
DNA methylation patterns are set up in a relatively fixed programmed manner during normal embryonic development and are then stably maintained. Using genome-wide analysis, we discovered a postnatal pathway involving...
4.
Sabag O, Zamir A, Keshet I, Hecht M, Ludwig G, Tabib A, et al.
Nat Struct Mol Biol
. 2013 Dec;
21(1):110-2.
PMID: 24336222
After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation...
5.
Michaelson-Cohen R, Keshet I, Straussman R, Hecht M, Cedar H, Beller U
Int J Gynecol Cancer
. 2011 Jan;
21(2):269-79.
PMID: 21270610
Background: DNA methylation regulates gene expression during development. The methylation pattern is established at the time of implantation. CpG islands are genome regions usually protected from methylation; however, selected islands...
6.
Lande-Diner L, Zhang J, Ben-Porath I, Amariglio N, Keshet I, Hecht M, et al.
J Biol Chem
. 2007 Feb;
282(16):12194-200.
PMID: 17311920
A large fraction of the animal genome is maintained in a transcriptionally repressed state throughout development. By generating viable Dnmt1(-)(/)(-) mouse cells we have been able to study the effect...
7.
Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, et al.
Nat Genet
. 2007 Jan;
39(2):232-6.
PMID: 17200670
Many genes associated with CpG islands undergo de novo methylation in cancer. Studies have suggested that the pattern of this modification may be partially determined by an instructive mechanism that...
8.
Keshet I, Schlesinger Y, Farkash S, Rand E, Hecht M, Segal E, et al.
Nat Genet
. 2006 Jan;
38(2):149-53.
PMID: 16444255
DNA methylation has a role in the regulation of gene expression during normal mammalian development but can also mediate epigenetic silencing of CpG island genes in cancer and other diseases....
9.
Rand E, Ben-Porath I, Keshet I, Cedar H
Curr Biol
. 2004 Jun;
14(11):1007-12.
PMID: 15182675
The H19 imprinted gene locus is regulated by an upstream 2 kb imprinting control region (ICR) that influences allele-specific expression, DNA methylation, and replication timing. This ICR becomes de novo...
10.
Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H
Nat Genet
. 2003 May;
34(2):187-92.
PMID: 12740577
DNA methylation inhibits gene expression in animal cells, probably by affecting chromatin structure. Biochemical studies suggest that this process may be mediated by methyl-specific binding proteins that recruit enzymatic machinery...