Establishment of Methylation Patterns in ES Cells

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2013 Dec 17

PMID 24336222

Citations 21

Authors

Ofra Sabag

Ayelet Zamir

Ilana Keshet

Merav Hecht

Guy Ludwig

Amalia Tabib

Joshua Moss

Howard Cedar

Affiliations

Soon will be listed here.

Abstract

After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell reprogramming.

Citing Articles

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