Ittai Ben-Porath
Overview
Explore the profile of Ittai Ben-Porath including associated specialties, affiliations and a list of published articles.
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29
Citations
3891
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Recent Articles
1.
Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, et al.
Nat Commun
. 2024 Jul;
15(1):6162.
PMID: 39039076
Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions. However, the identities and traits of these cells, and the potential for improving cancer therapy through their...
2.
Patra M, Klochendler A, Condiotti R, Kaffe B, Elgavish S, Drawshy Z, et al.
Nucleic Acids Res
. 2024 Apr;
52(11):6298-6316.
PMID: 38682582
Senescent cells can influence the function of tissues in which they reside, and their propensity for disease. A portion of adult human pancreatic beta cells express the senescence marker p16,...
3.
Alkhatib H, Rubinstein A, Vasudevan S, Flashner-Abramson E, Stefansky S, Roy Chowdhury S, et al.
Genome Med
. 2022 Oct;
14(1):120.
PMID: 36266692
Background: Drug resistance continues to be a major limiting factor across diverse anti-cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches...
4.
Gabai Y, Assouline B, Ben-Porath I
Trends Cancer
. 2022 Oct;
9(1):28-41.
PMID: 36208990
Cellular senescence forms a barrier to tumorigenesis, by inducing cell cycle arrest in damaged and mutated cells. However, once formed, senescent cells often emit paracrine signals that can either promote...
5.
Schachter N, Adams J, Skowron P, Kozma K, Lee C, Raghuram N, et al.
Nat Commun
. 2021 Sep;
12(1):5238.
PMID: 34475389
The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8...
6.
Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, et al.
Gut
. 2021 Mar;
71(2):345-355.
PMID: 33649045
Objective: Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent cells are present in premalignant pancreatic...
7.
Azazmeh N, Ben-Porath I
Mol Cell Oncol
. 2020 Nov;
7(6):1819752.
PMID: 33235916
p16 (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16 in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring...
8.
Azazmeh N, Assouline B, Winter E, Ruppo S, Nevo Y, Maly A, et al.
Nat Commun
. 2020 Jun;
11(1):2711.
PMID: 32483135
p16 (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16 accumulate in aging tissues and appear in premalignant lesions, yet their physiologic effects are...
9.
Borghesan M, Fafian-Labora J, Eleftheriadou O, Carpintero-Fernandez P, Paez-Ribes M, Vizcay-Barrena G, et al.
Cell Rep
. 2019 Jun;
27(13):3956-3971.e6.
PMID: 31242426
Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is important in...
10.
Granit R, Masury H, Condiotti R, Fixler Y, Gabai Y, Glikman T, et al.
Cell Rep
. 2018 Sep;
24(12):3237-3250.
PMID: 30232005
Differentiation events contribute to phenotypic cellular heterogeneity within tumors and influence disease progression and response to therapy. Here, we dissect mechanisms controlling intratumoral heterogeneity within triple-negative basal-like breast cancers. Tumor...