Ian W Dawes
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Explore the profile of Ian W Dawes including associated specialties, affiliations and a list of published articles.
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79
Citations
2388
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Recent Articles
21.
Aung-Htut M, Ayer A, Breitenbach M, Dawes I
Subcell Biochem
. 2011 Nov;
57:13-54.
PMID: 22094416
Oxidative damage to cellular constituents has frequently been associated with aging in a wide range of organisms. The power of yeast genetics and biochemistry has provided the opportunity to analyse...
22.
Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian T, et al.
PLoS Genet
. 2011 Aug;
7(7):e1002201.
PMID: 21829381
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipids. Little is known about how the size of LDs is controlled, although LDs of diverse...
23.
Wu M, ODoherty P, Fernandez H, Lyons V, Rogers P, Dawes I, et al.
FEMS Yeast Res
. 2011 Mar;
11(4):379-87.
PMID: 21375688
This report describes a biological screening system to measure the antioxidant capacity of compounds using the oxidant-induced growth arrest response of Saccharomyces cerevisiae. Alternative methods using the nonphysiological free radical...
24.
Lam Y, Aung-Htut M, Lim Y, Yang H, Dawes I
Free Radic Biol Med
. 2011 Jan;
50(8):963-70.
PMID: 21255640
Increased reactive oxygen species (ROS) are a feature of aging cells, but little is known about when ROS generation begins as cells age. Here we show how ROS change in...
25.
Chiu J, Tactacan C, Tan S, Lin R, Wouters M, Dawes I
J Biol Chem
. 2010 Dec;
286(7):5204-14.
PMID: 21147769
Yeast cells begin to bud and enter the S phase when growth conditions are favorable during the G(1) phase. When subjected to some oxidative stresses, cells delay entry at G(1),...
26.
Collinson E, Wimmer-Kleikamp S, Gerega S, Yang Y, Parish C, Dawes I, et al.
J Biol Chem
. 2010 Nov;
286(3):2205-14.
PMID: 21081499
Heme oxygenase-1 (HO-1) degrades heme and protects cells from oxidative challenge. This antioxidant activity is thought to result from the HO-1 enzymatic activity, manifested by a decrease in the concentration...
27.
Ayer A, Tan S, Grant C, Meyer A, Dawes I, Perrone G
Free Radic Biol Med
. 2010 Oct;
49(12):1956-68.
PMID: 20888410
Glutathione (GSH) is a key redox buffer and protectant. Growth (approx. one or two divisions) of cells lacking γ-glutamylcysteine synthetase (gsh1) in the absence of GSH led to irreversible respiratory...
28.
Lam Y, Stocker R, Dawes I
Free Radic Biol Med
. 2010 Apr;
49(2):237-44.
PMID: 20403425
Reactive oxygen species contribute to cellular ageing and an increased level of oxidative stress is often associated with ageing in many organisms. Supplementation of antioxidants has been advocated to decrease...
29.
Klinger H, Rinnerthaler M, Lam Y, Laun P, Heeren G, Klocker A, et al.
Exp Gerontol
. 2010 Apr;
45(7-8):533-42.
PMID: 20382214
Asymmetric segregation of oxidatively damaged proteins is discussed in the literature as a mechanism in cell division cycles which at the same time causes rejuvenation of the daughter cell and...
30.
Lin R, Weeks K, Gao X, Williams R, Bernardo B, Kiriazis H, et al.
Arterioscler Thromb Vasc Biol
. 2010 Mar;
30(4):724-32.
PMID: 20237330
Objective: Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. Activation of phosphoinositide 3-kinase [PI3K(p110 alpha)] is considered a new strategy for...