Ian W Dawes
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Explore the profile of Ian W Dawes including associated specialties, affiliations and a list of published articles.
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79
Citations
2388
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Recent Articles
11.
Thorpe G, Reodica M, Davies M, Heeren G, Jarolim S, Pillay B, et al.
Mol Biol Cell
. 2013 Jul;
24(18):2876-84.
PMID: 23864711
Reactive oxygen species (ROS) consist of potentially toxic, partly reduced oxygen species and free radicals. After H(2)O(2) treatment, yeast cells significantly increase superoxide radical production. Respiratory chain complex III and...
12.
Lee J, Tsoi A, Kornfeld G, Dawes I
FEMS Yeast Res
. 2013 Jul;
13(7):618-34.
PMID: 23837815
In addition to its other roles, L-serine functions in one-carbon metabolism and is interconvertable with glycine via serine hydroxymethyltransferases. However, the transcriptional response by Saccharomyces cerevisiae to L-serine addition is...
13.
Ayer A, Sanwald J, Pillay B, Meyer A, Perrone G, Dawes I
PLoS One
. 2013 Jun;
8(6):e65240.
PMID: 23762325
Responses to many growth and stress conditions are assumed to act via changes to the cellular redox status. However, direct measurement of pH-adjusted redox state during growth and stress has...
14.
Breitenbach M, Ralser M, Perrone G, Iglseder B, Rinnerthaler M, Dawes I
Front Biosci (Landmark Ed)
. 2013 Jun;
18(3):1174-93.
PMID: 23747875
In this chapter we are treating yeast cells as a model for oxidative stress response and the consequences of oxidative stress which are one cause for a number of human...
15.
Ta M, Kapterian T, Fei W, Du X, Brown A, Dawes I, et al.
FEBS J
. 2012 Sep;
279(22):4231-44.
PMID: 23013491
The isoprenoid squalene is an important precursor for the biosynthesis of sterols. The cellular storage of squalene and its impact on membrane properties have been the subject of recent investigations....
16.
Du X, Kazim A, Dawes I, Brown A, Yang H
Traffic
. 2012 Sep;
14(1):107-19.
PMID: 23009658
The exit of low-density lipoprotein derived cholesterol (LDL-C) from late endosomes (LE)/lysosomes (Ly) is mediated by Niemann-Pick C1 (NPC1), a multipass integral membrane protein on the limiting membranes of LE/Ly,...
17.
Ayer A, Fellermeier S, Fife C, Li S, Smits G, Meyer A, et al.
PLoS One
. 2012 Sep;
7(9):e44278.
PMID: 22970195
Maintenance of an optimal redox environment is critical for appropriate functioning of cellular processes and cell survival. Despite the importance of maintaining redox homeostasis, it is not clear how the...
18.
Chiu J, Dawes I
Trends Cell Biol
. 2012 Sep;
22(11):592-601.
PMID: 22951073
Cell proliferation is regulated by multiple signaling pathways and stress surveillance systems to ensure cell division takes place with fidelity. In response to oxidative stress, cells arrest in the cell-cycle...
19.
Gelling C, Dawes I, Perlmutter D, Fisher E, Brodsky J
Genetics
. 2012 Aug;
192(3):889-903.
PMID: 22923381
Up to 1 in 3000 individuals in the United States have α-1 antitrypsin deficiency, and the most common cause of this disease is homozygosity for the antitrypsin-Z variant (ATZ). ATZ...
20.
Breitenbach M, Laun P, Dickinson J, Klocker A, Rinnerthaler M, Dawes I, et al.
Subcell Biochem
. 2011 Nov;
57:55-78.
PMID: 22094417
This chapter reviews the role of mitochondria and of mitochondrial metabolism in the aging processes of yeast and the existing evidence for the "mitochondrial theory of aging mitochondrial theory of...