Chris M Grant
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Explore the profile of Chris M Grant including associated specialties, affiliations and a list of published articles.
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66
Citations
2220
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Recent Articles
1.
Creamer D, Beynon R, Hubbard S, Ashe M, Grant C
Cell Rep
. 2024 Jun;
43(6):114360.
PMID: 38865242
Protein kinase A (PKA) is a conserved kinase crucial for fundamental biological processes linked to growth, development, and metabolism. The PKA catalytic subunit is expressed as multiple isoforms in diverse...
2.
Carter Z, Creamer D, Kouvidi A, Grant C
PLoS Genet
. 2024 Feb;
20(2):e1011194.
PMID: 38422160
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they can be sequestered to specific sites within cells...
3.
Kershaw C, Nelson M, Castelli L, Jennings M, Lui J, Talavera D, et al.
J Biol Chem
. 2023 Aug;
299(10):105195.
PMID: 37633333
The regulation of translation provides a rapid and direct mechanism to modulate the cellular proteome. In eukaryotes, an established model for the recruitment of ribosomes to mRNA depends upon a...
4.
Cunningham J, Sfakianos A, Kritsiligkou P, Kershaw C, Whitmarsh A, Hubbard S, et al.
Nucleic Acids Res
. 2023 Jul;
51(16):8820-8835.
PMID: 37449412
Translation initiation factor 4G (eIF4G) is an integral component of the eIF4F complex which is key to translation initiation for most eukaryotic mRNAs. Many eIF4G isoforms have been described in...
5.
Schepers J, Carter Z, Kritsiligkou P, Grant C
Antioxidants (Basel)
. 2023 Feb;
12(2).
PMID: 36829961
Prions are self-propagating, misfolded forms of proteins associated with various neurodegenerative diseases in mammals and heritable traits in yeast. How prions form spontaneously into infectious amyloid-like structures without underlying genetic...
6.
Rusilowicz M, Newman D, Creamer D, Johnson J, Adair K, Harman V, et al.
J Proteome Res
. 2023 Jan;
22(2):594-604.
PMID: 36688735
Protein quantitation via mass spectrometry relies on peptide proxies for the parent protein from which abundances are estimated. Owing to the variability in signal from individual peptides, accurate absolute quantitation...
7.
Kan K, Nelson M, Grant C, Hubbard S, Lu H
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430179
Mitochondrial i-AAA proteinase Yme1 is a multifunctional protein that plays important roles in maintaining mitochondrial protein homeostasis and regulating biogenesis and function of mitochondrial proteins. However, due to the complex...
8.
Creamer D, Hubbard S, Ashe M, Grant C
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883514
Eukaryotic cells have developed a complex circuitry of signalling molecules which monitor changes in their intra- and extracellular environments. One of the most widely studied signalling pathways is the highly...
9.
Kershaw C, Nelson M, Lui J, Bates C, Jennings M, Hubbard S, et al.
RNA Biol
. 2021 Oct;
18(sup2):655-673.
PMID: 34672913
Non-membrane-bound compartments such as P-bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. We have systematically and quantitatively determined the protein...
10.
Jamar N, Kritsiligkou P, Grant C
Sci Rep
. 2021 Aug;
11(1):16722.
PMID: 34385503
No abstract available.