Ian R Baxendale
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Explore the profile of Ian R Baxendale including associated specialties, affiliations and a list of published articles.
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92
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1288
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Recent Articles
1.
Tinivella A, Banchi M, Gambacorta G, Borghi F, Orlandi P, Baxendale I, et al.
ACS Pharmacol Transl Sci
. 2023 Dec;
6(12):1870-1883.
PMID: 38093846
Estrogen deficiency derived from inhibition of estrogen biosynthesis is a typical condition of postmenopausal women and breast cancer (BCs) patients undergoing antihormone therapy. The ensuing increase in aldosterone levels is...
2.
Sharley J, Gambacorta G, Perez A, Ferri E, Miranda A, Quesada J, et al.
Data Brief
. 2022 Dec;
46:108801.
PMID: 36569533
The dataset of spectroscopic analysis performed on starting materials, intermediates, and products relating to the synthesis of Hedione are hereby presented. The data were acquired in Durham university during the...
3.
Cerra B, Venturoni F, Souma M, Ceccarelli G, Lozza A, Passeri D, et al.
Eur J Med Chem
. 2022 Sep;
242:114652.
PMID: 36049273
Herein we report our synthetic efforts in supporting the development of the bile alcohol sulfate INT-767, a FXR/TGR5 dual agonist with remarkable therapeutic potential for liver disorders. We describe the...
4.
Dogan T, Akhan Guzelcan E, Baumann M, Koyas A, Atas H, Baxendale I, et al.
PLoS Comput Biol
. 2021 Nov;
17(11):e1009171.
PMID: 34843456
Predictive approaches such as virtual screening have been used in drug discovery with the objective of reducing developmental time and costs. Current machine learning and network-based approaches have issues related...
5.
Murie V, Nicolino P, Dos Santos T, Gambacorta G, Nishimura R, Perovani I, et al.
J Org Chem
. 2021 Sep;
86(19):13402-13419.
PMID: 34553940
We have prepared a library of functionalized quinolines through the magnesiation of 7-chloroquinolines under mild conditions, employing both batch and continuous flow conditions. The preparation involved the generation of mixed...
6.
Gambacorta G, Sharley J, Baxendale I
Beilstein J Org Chem
. 2021 Jun;
17:1181-1312.
PMID: 34136010
Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review...
7.
Suster C, Baxendale I, Mihovilovic M, Stanetty C
Front Chem
. 2020 Aug;
8:625.
PMID: 32850647
Bacterial lipopolysaccharides (LPS) are important bio-medical structures, playing a major role in the interaction with human immune systems. Their core regions, containing multiple units of l--d- heptoses (l,d-heptose), are highly...
8.
Gambacorta G, Apperley D, Baxendale I
Molecules
. 2020 May;
25(9).
PMID: 32380725
The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We...
9.
Ruggeri M, Dombrowski A, Djuric S, Baxendale I
J Org Chem
. 2020 May;
85(11):7276-7286.
PMID: 32369365
A novel rearrangement sequence of 3-hydroxyazetidines via a Ritter initiated cascade provides highly substituted 2-oxazolines in high yields. The reaction conditions and substrate scope of the transformation have been studied...
10.
Nicholls A, Batsanov A, Baxendale I
Molecules
. 2019 Nov;
24(22).
PMID: 31744074
A simple protocol yielding -substituted nitrosophenols from phenols is demonstrated, in the form of copper(II) (nitrosophenolato) complexes. The developed methodology was applied to a range of substrates, confirming the role...