Steven V Ley
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Explore the profile of Steven V Ley including associated specialties, affiliations and a list of published articles.
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Articles
259
Citations
2967
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Recent Articles
1.
Schafer S, Voll A, Bracher A, Ley S, Hausch F
Bioorg Med Chem Lett
. 2024 Apr;
104:129728.
PMID: 38582133
Antascomicin B is a natural product that similarly to the macrolides FK506 and Rapamycin binds to the FK506-binding protein 12 (FKBP12). FK506 and Rapamycin act as molecular glues by inducing...
2.
Alfano A, Garcia-Lacuna J, Griffiths O, Ley S, Baumann M
Chem Sci
. 2024 Mar;
15(13):4618-4630.
PMID: 38550700
This article defines the role that continuous flow chemistry can have in new reaction discovery, thereby creating molecular assembly opportunities beyond our current capabilities. Most notably the focus is based...
3.
Gatarz S, Griffiths O, Esteves H, Jiao W, Morse P, Fisher E, et al.
J Org Chem
. 2024 Jan;
89(3):1898-1909.
PMID: 38239107
A method to assemble (hetero)aryl sulfonamides via the reductive coupling of aryl sulfinates and nitroarenes is reported. Various reducing conditions with sodium bisulfite and with or without tin(II) chloride in...
4.
Griffiths O, Esteves H, Emmet D, Ley S
Chemistry
. 2023 Dec;
30(12):e202303976.
PMID: 38116896
Sulfonyl groups are widely observed in biologically relevant molecules and consequently, SO capture is an increasingly attractive method to prepare these sulfonyl-containing compounds given the range of SO -surrogates now...
5.
Bourne S, Amann F, Ley S
Chimia (Aarau)
. 2023 Dec;
77(5):288-293.
PMID: 38047823
This article seeks to provide an overview of the environmental factors within the pharmaceutical industry that have contributed to the emergence of flow chemistry over the past two decades. It...
6.
Griffiths O, Ley S
J Org Chem
. 2022 Sep;
87(19):13204-13223.
PMID: 36103403
-heterospirocycles are interesting structural units found in both natural products and medicinal compounds but have relatively few reliable methods for their synthesis. Here, we enlist the photocatalytic generation of -centered...
7.
Griffiths O, Esteves H, Chen Y, Sowa K, May O, Morse P, et al.
J Org Chem
. 2021 Sep;
86(19):13559-13571.
PMID: 34524825
Executing photoredox reactions in flow offers solutions to frequently encountered issues regarding reproducibility, reaction time, and scale-up. Here, we report the transfer of a photoredox-catalyzed benzylic coupling of alkylarenes to...
8.
Roy S, Sipthorp J, Mahata B, Pramanik J, Hennrich M, Gavin A, et al.
iScience
. 2021 May;
24(5):102485.
PMID: 34036248
Pregnenolone (P5) promotes prostate cancer cell growth, and synthesis of intratumoural P5 is a potential cause of development of castration resistance. Immune cells can also synthesize P5 . Despite its...
9.
Pastre J, Murray P, Browne D, Brancaglion G, Galaverna R, Pilli R, et al.
ACS Omega
. 2020 Aug;
5(29):18472-18483.
PMID: 32743225
An integrated batch and continuous flow process has been developed for the gram-scale synthesis of goniothalamin. The synthetic route hinges upon a telescoped continuous flow Grignard addition followed by an...
10.
Cao L, Kabeshov M, Ley S, Lapkin A
Beilstein J Org Chem
. 2020 Jul;
16:1465-1475.
PMID: 32647548
A computational approach has been developed to automatically generate and analyse the structures of the intermediates of palladium-catalysed carbon-hydrogen (C-H) activation reactions as well as to predict the final products....