Iain R Greig
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Explore the profile of Iain R Greig including associated specialties, affiliations and a list of published articles.
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25
Citations
484
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Recent Articles
11.
Tseng C, Noordali H, Sani M, Madhani M, Grant D, Frenneaux M, et al.
J Med Chem
. 2017 Mar;
60(7):2780-2789.
PMID: 28277663
We designed and synthesized perhexiline analogues that have the same therapeutic profile as the parent cardiovascular drug but lacking its metabolic liability associated with CYP2D6 metabolism. Cycloalkyl perhexiline analogues 6a-j...
12.
Greig I, Baillie G, Abdelrahman M, Trembleau L, Ross R
Bioorg Med Chem Lett
. 2016 Aug;
26(18):4403-4407.
PMID: 27542310
Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not...
13.
Ignatowska-Jankowska B, Baillie G, Kinsey S, Crowe M, Ghosh S, Owens R, et al.
Neuropsychopharmacology
. 2015 Jun;
40(13):2948-59.
PMID: 26052038
The CB1 receptor represents a promising target for the treatment of several disorders including pain-related disease states. However, therapeutic applications of Δ(9)-tetrahydrocannabinol and other CB1 orthosteric receptor agonists remain limited...
14.
Poklis J, Clay D, Ignatowska-Jankowska B, Zanato C, Ross R, Greig I, et al.
J Anal Toxicol
. 2015 Mar;
39(5):353-8.
PMID: 25737338
A high-performance liquid chromatography tandem mass spectrometry method was developed for the detection and quantification of 6-methyl-3-(2-nitro-1-(thiophen-2-yl)propyl)-2-phenyl-1H-indole (ZCZ-011) using 2-phenylindole as the internal standard (ISTD). ZCZ-011 was synthesized as a...
15.
Gamage T, Ignatowska-Jankowska B, Wiley J, Abdelrahman M, Trembleau L, Greig I, et al.
Behav Pharmacol
. 2014 Mar;
25(2):182-5.
PMID: 24603340
Several allosteric modulators (AMs) of the CB1 receptor have been characterized in vitro, including Org27569, which enhances CB1-specific binding of [H]CP55,940, but behaves as an insurmountable CB1-receptor antagonist in several...
16.
Coste E, Greig I, Mollat P, Rose L, Gray M, Ralston S, et al.
Ann Rheum Dis
. 2013 Oct;
74(1):220-6.
PMID: 24095938
Introduction: Inflammatory joint diseases such as rheumatoid arthritis are associated with local bone erosions and systemic bone loss, mediated by increased osteoclastic activity. The receptor activator of nuclear factor (NF)...
17.
Shankar S, Jagodzinska M, Malpezzi L, Lazzari P, Manca I, Greig I, et al.
Org Biomol Chem
. 2013 Feb;
11(14):2273-87.
PMID: 23411563
Tubulysins are cytotoxic natural products with promising anti-cancer properties, originally isolated from myxobacterial cultures. Structurally, tubulysins are tetrapeptides, incorporating three unusual (Mep, Tuv and Tup) and one proteinogenic amino acid...
18.
Greig I, Coste E, Ralston S, van t Hof R
Bioorg Med Chem Lett
. 2012 Dec;
23(3):816-20.
PMID: 23265887
Triaylsulfonamides were identified as novel anti-inflammatory agents, acting by inhibition of RANKL and TNFα signaling. Structure-activity studies led to the identification of compounds with in vitro potencies of <100 nM...
19.
Anavi-Goffer S, Baillie G, Irving A, Gertsch J, Greig I, Pertwee R, et al.
J Biol Chem
. 2011 Oct;
287(1):91-104.
PMID: 22027819
GPR55 is activated by l-α-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In this study, we investigated the GPR55 pharmacology of various cannabinoids, including analogues of the CB1 receptor antagonist Rimonabant®,...
20.
Idris A, Coste E, Greig I, Ralston S, Vant Hof R
Calcif Tissue Int
. 2010 Sep;
87(6):525-32.
PMID: 20852852
We previously described a novel series of biphenyl carboxylic acid derivatives which have potent antiresorptive effects in vitro and in vivo and do not affect osteoblast function. However, none of...