Iain R Greig
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Explore the profile of Iain R Greig including associated specialties, affiliations and a list of published articles.
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25
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484
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Recent Articles
21.
Greig I, Coste E, Ralston S, Vant Hof R
Bioorg Med Chem Lett
. 2010 Aug;
20(18):5548-51.
PMID: 20692834
Biphenylketones were identified as novel inhibitors of NFkappaB activation. Structure-activity studies led to the identification of compound 4c, which had good potency against osteoclasts (IC50=0.8 microM), showed oral activity, and...
22.
Idris A, Greig I, Bassonga-Landao E, Ralston S, van t Hof R
Endocrinology
. 2008 Sep;
150(1):5-13.
PMID: 18772231
Bisphosphonates are widely used in the treatment of osteoporosis, but they inhibit bone formation and blunt the anabolic effect of PTH. Here we describe a novel series of compounds that...
23.
Idris A, Rojas J, Greig I, Vant Hof R, Ralston S
Calcif Tissue Int
. 2008 Feb;
82(3):191-201.
PMID: 18259679
Bisphosphonates are widely used for the treatment of bone diseases associated with increased osteoclastic bone resorption. Bisphosphonates are known to inhibit biochemical markers of bone formation in vivo, but it...
24.
Greig I, Idris A, Ralston S, Vant Hof R
J Med Chem
. 2006 Dec;
49(25):7487-92.
PMID: 17149877
Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. We have identified...
25.
Idris A, van t Hof R, Greig I, Ridge S, Baker D, Ross R, et al.
Nat Med
. 2005 May;
11(7):774-9.
PMID: 15908955
Accelerated osteoclastic bone resorption has a central role in the pathogenesis of osteoporosis and other bone diseases. Identifying the molecular pathways that regulate osteoclast activity provides a key to understanding...
26.
Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors
van t Hof R, Idris A, Ridge S, Dunford J, Greig I, Ralston S
J Bone Miner Res
. 2004 Sep;
19(10):1651-60.
PMID: 15355560
Unlabelled: A novel class of biphenylcarboxylic acid derivatives are described that inhibit osteoclastic bone resorption in vitro by promoting osteoclast apoptosis and that prevent ovariectomy-induced bone loss in vivo. The...