I David Goldman
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Explore the profile of I David Goldman including associated specialties, affiliations and a list of published articles.
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77
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2727
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Recent Articles
1.
Nandigrami P, Goldman I, Fiser A
J Biol Chem
. 2025 Feb;
301(3):108280.
PMID: 39924111
Hereditary folate malabsorption (HFM) is a rare, autosomal recessive disorder characterized by impaired intestinal absorption and impaired transport of folates across the choroid plexus into cerebral spinal fluid due to...
2.
Parker J, Deme J, Kuteyi G, Wu Z, Huo J, Goldman I, et al.
Nature
. 2021 May;
595(7865):130-134.
PMID: 34040256
Folates (also known as vitamin B9) have a critical role in cellular metabolism as the starting point in the synthesis of nucleic acids, amino acids and the universal methylating agent...
3.
Zhan H, Najmi M, Lin K, Aluri S, Fiser A, Goldman I, et al.
J Biol Chem
. 2020 Sep;
295(46):15650-15661.
PMID: 32893190
The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus. Recent work has identified a F392V mutation causing hereditary folate malabsorption. However,...
4.
Alam C, Aufreiter S, Georgiou C, Hoque M, Finnell R, OConnor D, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(35):17531-17540.
PMID: 31405972
Folates are critical for central nervous system function. Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRα/Folr1), known...
5.
Aluri S, Zhao R, Lin K, Shin D, Fiser A, Goldman I
J Biol Chem
. 2019 Mar;
294(18):7245-7258.
PMID: 30858177
The proton-coupled folate transporter (PCFT) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus. Substitutions at Asp-109 in the first intracellular loop...
6.
Aluri S, Zhao R, Lubout C, Goorden S, Fiser A, Goldman I
Blood Adv
. 2018 Jan;
2(1):61-68.
PMID: 29344585
Hereditary folate malabsorption (HFM) is an autosomal recessive disorder characterized by impaired intestinal folate absorption and impaired folate transport across the choroid plexus due to loss of function of the...
7.
Zhao R, Najmi M, Aluri S, Spray D, Goldman I
Mol Pharmacol
. 2018 Jan;
93(3):208-215.
PMID: 29326243
The proton-coupled folate transporter (PCFT) is ubiquitously expressed in solid tumors to which it delivers antifolates, particularly pemetrexed, into cancer cells. Studies of PCFT-mediated transport, to date, have focused exclusively...
8.
Aluri S, Zhao R, Fiser A, Goldman I
Am J Physiol Cell Physiol
. 2017 Nov;
314(3):C289-C296.
PMID: 29167151
The proton-coupled folate transporter (PCFT-SLC46A1) is required for folate transport across the apical membrane of the small intestine and across the choroid plexus. This study focuses on the structure/function of...
9.
Alam C, Hoque M, Finnell R, Goldman I, Bendayan R
Mol Pharm
. 2017 Sep;
14(11):3848-3858.
PMID: 28885847
Folates are essential for brain development and function. Folate transport in mammalian tissues is mediated by three major folate transport systems, i.e., reduced folate carrier (RFC), proton-coupled folate transporter (PCFT),...
10.
Aluri S, Zhao R, Fiser A, Goldman I
Biochim Biophys Acta Biomembr
. 2017 Aug;
1859(11):2193-2202.
PMID: 28802835
The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and folate transport across the choroid plexus. This report addresses the structure/function of the 8th transmembrane helix. Based upon...