Hubert Koster
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Explore the profile of Hubert Koster including associated specialties, affiliations and a list of published articles.
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10
Citations
211
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Recent Articles
1.
Bahr S, Rue R, Smith C, Evans J, Koster H, Krymskaya V, et al.
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456169
Lymphangioleiomyomatosis (LAM) is a rare genetic lung disease. Unfortunately, treatment with the mTORC1 inhibitor Rapamycin only slows disease progression, and incomplete responses are common. Thus, there remains an urgent need...
2.
Blex C, Michaelis S, Schrey A, Furkert J, Eichhorst J, Bartho K, et al.
Chembiochem
. 2017 May;
18(16):1639-1649.
PMID: 28557180
Unbiased chemoproteomic profiling of small-molecule interactions with endogenous proteins is important for drug discovery. For meaningful results, all protein classes have to be tractable, including G protein-coupled receptors (GPCRs). These...
3.
Joosten M, Ginzel S, Blex C, Schmidt D, Gombert M, Chen C, et al.
Mol Oncol
. 2016 Jun;
10(8):1232-44.
PMID: 27324824
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B-cell lymphomas, although a subset of patients with refractory or...
4.
Lenger J, Kaschani F, Lenz T, Dalhoff C, Villamor J, Koster H, et al.
Bioorg Med Chem
. 2011 Jul;
20(2):592-6.
PMID: 21775155
Matrix metalloproteases (MMPs) are secreted or membrane-bound zinc-containing proteases that play diverse roles in development and immunity in plants and in tissue remodeling in animals. We developed a photoreactive probe...
5.
Lenz T, Poot P, Grabner O, Glinski M, Weinhold E, Dreger M, et al.
J Vis Exp
. 2010 Dec;
(46).
PMID: 21189471
There is a variety of approaches to reduce the complexity of the proteome on the basis of functional small molecule-protein interactions such as affinity chromatography (1) or Activity Based Protein...
6.
Dalhoff C, Huben M, Lenz T, Poot P, Nordhoff E, Koster H, et al.
Chembiochem
. 2010 Jan;
11(2):256-65.
PMID: 20049756
Understanding the interplay of different cellular proteins and their substrates is of major interest in the postgenomic era. For this purpose, selective isolation and identification of proteins from complex biological...
7.
Luo Y, Blex C, Baessler O, Glinski M, Dreger M, Sefkow M, et al.
Mol Cell Proteomics
. 2009 Sep;
8(12):2843-56.
PMID: 19741253
The profiling of subproteomes from complex mixtures on the basis of small molecule interactions shared by members of protein families or small molecule interaction domains present in a subset of...
8.
Koster H, Little D, Luan P, Muller R, Siddiqi S, Marappan S, et al.
Assay Drug Dev Technol
. 2007 Jul;
5(3):381-90.
PMID: 17638538
One of the major hurdles in the post-genomic era is to understand the function of genes and the interplay of many different cellular proteins. This is especially important for drug...
9.
Jurinke C, Van Den Boom D, Cantor C, Koster H
Adv Biochem Eng Biotechnol
. 2002 Sep;
77:57-74.
PMID: 12227737
This chapter will explore the role of mass spectrometry (MS) as a detection method for genotyping applications and will illustrate how MS evolved from an expert-user-technology to a routine laboratory...
10.
Jurinke C, Van Den Boom D, Cantor C, Koster H
Methods Mol Biol
. 2002 May;
187:179-92.
PMID: 12013745
No abstract available.