Michael Sefkow
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Explore the profile of Michael Sefkow including associated specialties, affiliations and a list of published articles.
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19
Citations
177
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Recent Articles
1.
Bartoloni M, Jin X, Marcaida M, Banha J, Dibonaventura I, Bongoni S, et al.
Chem Sci
. 2018 Jun;
6(10):5473-5490.
PMID: 29861888
Double cyclization of short linear peptides obtained by solid phase peptide synthesis was used to prepare bridged bicyclic peptides (BBPs) corresponding to the topology of bridged bicyclic alkanes such as...
2.
Blex C, Michaelis S, Schrey A, Furkert J, Eichhorst J, Bartho K, et al.
Chembiochem
. 2017 May;
18(16):1639-1649.
PMID: 28557180
Unbiased chemoproteomic profiling of small-molecule interactions with endogenous proteins is important for drug discovery. For meaningful results, all protein classes have to be tractable, including G protein-coupled receptors (GPCRs). These...
3.
Joosten M, Ginzel S, Blex C, Schmidt D, Gombert M, Chen C, et al.
Mol Oncol
. 2016 Jun;
10(8):1232-44.
PMID: 27324824
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B-cell lymphomas, although a subset of patients with refractory or...
4.
von Kleist L, Michaelis S, Bartho K, Graebner O, Schlief M, Dreger M, et al.
J Med Chem
. 2016 Apr;
59(10):4664-75.
PMID: 27074629
Structurally related inhibitors of a shared therapeutic target may differ regarding potential toxicity issues that are caused by different off-target bindings. We devised a differential competition capture compound mass spectrometry...
5.
Brown L, Baranowski M, Wang Y, Schrey A, Lenz T, Taverna S, et al.
Anal Biochem
. 2014 Aug;
467:14-21.
PMID: 25172130
S-Adenosyl-l-methionine (SAM) is recognized as an important cofactor in a variety of biochemical reactions. As more proteins and pathways that require SAM are discovered, it is important to establish a...
6.
Coy-Barrera E, Cuca-Suarez L, Sefkow M, Schilde U
Acta Crystallogr C
. 2012 Aug;
68(Pt 8):o320-2.
PMID: 22850860
The structure of naturally-occurring cinerin C [systematic name: (7S,8R,3'R,4'S,5'R)-Δ(8')-4'-hydroxy-5,5',3'-trimethoxy-3,4-methylenedioxy-2',3',4',5'-tetrahydro-2'-oxo-7.3',8.5'-neolignan], isolated from the ethanol extract of leaves of Pleurothyrium cinereum (Lauraceae), has previously been established by NMR and HRMS spectroscopy, and...
7.
Michaelis S, Marais A, Schrey A, Graebner O, Schaudt C, Sefkow M, et al.
J Med Chem
. 2012 Apr;
55(8):3934-44.
PMID: 22494098
Recent studies have revealed that compounds believed to be highly selective frequently address multiple target proteins. We investigated the protein interaction profile of the widely prescribed thrombin inhibitor dabigatran (1),...
8.
Fischer J, Dalhoff C, Schrey A, Graebner O, Michaelis S, Andrich K, et al.
J Proteomics
. 2011 Jun;
75(1):160-8.
PMID: 21664307
Capture Compound Mass Spectrometry (CCMS) is a platform technology for the functional isolation of subproteomes. Here we report the synthesis of two new kinase Capture Compounds (CCs) based on the...
9.
Coy B E, Cuca S L, Sefkow M
Org Biomol Chem
. 2010 Apr;
8(9):2003-5.
PMID: 20401372
The first diastereoselective synthesis of PAF-antagonistic cinerins A-C, macrophyllin-type bicyclo[3.2.1]octane neolignans from Pleurothyrium cinereum, has been accomplished using a novel Pd-catalysed oxyarylation to afford a 2,3-dihydrobenzofuran as the key intermediate.
10.
Coy E, Jovanovic L, Sefkow M
Org Lett
. 2010 Mar;
12(9):1976-9.
PMID: 20337490
An efficient and facile synthesis of trans-dihydrobenzofurans has been accomplished from o-aminophenols and phenylpropenes via a novel (one-pot) diastereoselective Pd-catalyzed oxyarylation reaction. The development and optimization of this method is...