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Huachao Bin

Explore the profile of Huachao Bin including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 39
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Linli Li
Shengyong Yang
Bo Mu
Guifeng Lin
Falu Wang
Pei Chen
Jinshan Nan
Shulei Pan
Chenyu Tian
Wei Yang
Published In
Eur J Med Chem
J Med Chem
Nat Commun
Bioorg Med Chem Lett
Affiliations
Soon will be listed here.
Recent Articles
1.
Non-classical ferroptosis inhibition by a small molecule targeting PHB2
Yang W, Mu B, You J, Tian C, Bin H, Xu Z, et al.
Nat Commun . 2022 Dec; 13(1):7473. PMID: 36463308
Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a variety of diseases. Currently, a...
2.
Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors
Chen P, Bin H, Jiao Y, Lin G, Zhang Y, Xia A, et al.
Bioorg Med Chem Lett . 2022 Mar; 63:128651. PMID: 35245663
Ataxia telangiectasia and Rad3-related (ATR) kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing replication stress (RS), and has been considered as a potential...
3.
Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo
Bin H, Chen P, Wu M, Wang F, Lin G, Pan S, et al.
Eur J Med Chem . 2022 Feb; 232:114187. PMID: 35183872
Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is an important regulator of the DNA damage response (DDR), especially in response to replication stress (RS). Tumor cells with ataxia-telangiectasia mutated (ATM)...
4.
Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis
Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, et al.
Eur J Med Chem . 2022 Feb; 232:114194. PMID: 35183871
The NLRP3 inflammasome, which regulated a proinflammatory programmed cell death form termed pyroptosis, is involved in the pathological process of various human diseases, such as multiple sclerosis, type 2 diabetes,...
5.
Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6-pyrimido[5,4-][1,4]oxazin-7(8)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants
Pan S, Zhang L, Luo X, Nan J, Yang W, Bin H, et al.
J Med Chem . 2022 Jan; 65(3):2035-2058. PMID: 35080890
Tropomyosin receptor kinases (TrkA, TrkB, and TrkC) are attractive therapeutic targets for multiple cancers. Two first-generation small-molecule Trks inhibitors, larotrectinib and entrectinib, have just been approved to use clinically. However,...