Falu Wang
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Explore the profile of Falu Wang including associated specialties, affiliations and a list of published articles.
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9
Citations
86
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Recent Articles
1.
Wang F, Zeng R, Qiao J, Xia A, Li Y, Li F, et al.
Bioorg Med Chem Lett
. 2023 Jul;
92:129407.
PMID: 37437852
The COVID-19 pandemic has caused people immense suffering all over the world. Although the World Health Organization (WHO) has announced the end of the pandemic, the sporadic virus epidemic is...
2.
Huang C, Shuai H, Qiao J, Hou Y, Zeng R, Xia A, et al.
Signal Transduct Target Ther
. 2023 Mar;
8(1):128.
PMID: 36928316
Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health. Small molecule antivirals are an effective treatment strategy to fight against the virus. However,...
3.
Li Y, Zhang L, Wang Y, Zou J, Yang R, Luo X, et al.
Nat Commun
. 2022 Nov;
13(1):6891.
PMID: 36371441
The retrieval of hit/lead compounds with novel scaffolds during early drug development is an important but challenging task. Various generative models have been proposed to create drug-like molecules. However, the...
4.
Bin H, Chen P, Wu M, Wang F, Lin G, Pan S, et al.
Eur J Med Chem
. 2022 Feb;
232:114187.
PMID: 35183872
Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is an important regulator of the DNA damage response (DDR), especially in response to replication stress (RS). Tumor cells with ataxia-telangiectasia mutated (ATM)...
5.
Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, et al.
Eur J Med Chem
. 2022 Feb;
232:114194.
PMID: 35183871
The NLRP3 inflammasome, which regulated a proinflammatory programmed cell death form termed pyroptosis, is involved in the pathological process of various human diseases, such as multiple sclerosis, type 2 diabetes,...
6.
Pan S, Zhang L, Luo X, Nan J, Yang W, Bin H, et al.
J Med Chem
. 2022 Jan;
65(3):2035-2058.
PMID: 35080890
Tropomyosin receptor kinases (TrkA, TrkB, and TrkC) are attractive therapeutic targets for multiple cancers. Two first-generation small-molecule Trks inhibitors, larotrectinib and entrectinib, have just been approved to use clinically. However,...
7.
Di J, He H, Wang F, Xue F, Liu X, Qin Y
Chem Commun (Camb)
. 2018 Apr;
54(37):4692-4695.
PMID: 29676430
A photoredox-mediated, regiospecific alkyl addition reaction of (hetero)arene-fused thiophenes has been developed, employing bench-stable N-benzoyl alkyl-sulfinamides as the alkyl sources. This protocol offers a unique desulfuration approach to generate alkyl...
8.
Xue F, Wang F, Liu J, Di J, Liao Q, Lu H, et al.
Angew Chem Int Ed Engl
. 2018 Apr;
57(22):6667-6671.
PMID: 29671934
Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible-light photoredox catalysis. A process that involves the generation of N-centered radicals from sulfinamide...
9.
Leng L, Zhou X, Liao Q, Wang F, Song H, Zhang D, et al.
Angew Chem Int Ed Engl
. 2017 Feb;
56(13):3703-3707.
PMID: 28230294
The asymmetric total syntheses of a group of structurally complex Kopsia alkaloids, (-)-kopsine, (-)-isokopsine, (+)-methyl chanofruticosinate, (-)-fruticosine, and (-)-kopsanone, has been achieved. The key strategies for the construction of the...