Guifeng Lin
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Explore the profile of Guifeng Lin including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
149
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Recent Articles
1.
Yang X, Zhou P, Shen S, Hu Q, Tian C, Xia A, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(30):e2401091121.
PMID: 39024109
Achieving ligand subtype selectivity within highly homologous subtypes of G-protein-coupled receptor (GPCR) is critical yet challenging for GPCR drug discovery, primarily due to the unclear mechanism underlying ligand subtype selectivity,...
2.
Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(24):e2321532121.
PMID: 38830102
is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis, Δ9-tetrahydrocannabinol (THC), and other agonists engage the orthosteric site...
3.
Zhou X, Yang X, Huang S, Lin G, Lei K, Wang Q, et al.
Adv Sci (Weinh)
. 2024 May;
11(26):e2308786.
PMID: 38696610
N6-methyladenosine (mA) modification, installed by METTL3-METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role in oral mucosal immunity remains ambiguous. Periodontitis is a special but prevalent infectious...
4.
Lin G, Xia A, Qiao J, Zhang H, Chen P, Zhou P, et al.
Biochem Pharmacol
. 2024 Apr;
224:116217.
PMID: 38641306
The Hippo pathway is a key regulator of tissue growth, organ size, and tumorigenesis. Activating the Hippo pathway by gene editing or pharmaceutical intervention has been proven to be a...
5.
Zhou N, Zhang Y, Jiao Y, Nan J, Xia A, Mu B, et al.
Int Immunopharmacol
. 2023 Dec;
127:111314.
PMID: 38081102
Pyroptosis is a proinflammatory type of regulated cell death and has been involved in many pathological processes. Inhibition of pyroptosis is thought to be a promising strategy for the treatment...
6.
Zhou P, Zhao J, Hu Q, Lin G, Zhang J, Xia A, et al.
Bioorg Med Chem Lett
. 2023 Nov;
97:129548.
PMID: 37949379
GPR34 is a rhodopsin-like class G protein-coupled receptor (GPCR) that is involved in the development and progression of several diseases. Despite its importance, effective targeting strategies are lacking. We herein...
7.
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2308435120.
PMID: 37733739
GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report a cryo-electron microscopy (cryo-EM) structure of GPR34...
8.
Zhang S, Zhou P, Liu J, Xia A, Lin G, Xiang Z, et al.
ACS Med Chem Lett
. 2023 Jun;
14(6):746-756.
PMID: 37312863
Ataxia-telangiectasia mutated (ATM) is an atypical serine/threonine protein kinase which is implicated in the repair of DNA double-strand breaks. Numerous reports have shown that ATM inhibition is an attractive target...
9.
Nan J, Liu J, Lin G, Zhang S, Xia A, Zhou P, et al.
J Med Chem
. 2023 Feb;
66(5):3460-3483.
PMID: 36821347
Selectively targeting the cannabinoid receptor CB2 is an attractive therapeutic strategy for the treatment of inflammatory pain without psychiatric side effects mediated by the cannabinoid receptor CB1. Herein, we report...
10.
Zhang Y, Zhou N, Jiao Y, Lin G, Li X, Gao S, et al.
Invest Ophthalmol Vis Sci
. 2023 Jan;
64(1):1.
PMID: 36595275
Purpose: Pyroptosis, a novel proinflammatory programmed cell death, has been implicated in some ocular diseases. Of special note is the noncanonical pyroptosis that has recently been recognized to play a...