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Howard C Masuoka

Explore the profile of Howard C Masuoka including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 891
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Recent Articles
1.
Willy J, Young S, Mosley A, Gawrieh S, Stevens J, Masuoka H, et al.
J Biol Chem . 2017 Jul; 292(34):14050-14065. PMID: 28710282
Nonalcoholic fatty liver disease (steatosis) is the most prevalent liver disease in the Western world. One of the advanced pathologies is nonalcoholic steatohepatitis (NASH), which is associated with induction of...
2.
Gromski M, Peng J, Zhou J, Masuoka H, Suvannasankha A, Liangpunsakul S
J Investig Med High Impact Case Rep . 2017 Feb; 4(4):2324709616683721. PMID: 28203570
Primary gastrointestinal (GI) lymphoma is a heterogeneous disease with varied clinical presentations. The stomach is the most common GI site and accounts for 70% to 75% of GI lymphomas. We...
3.
Masuoka H, Vuppalanchi R, Deppe R, Bybee P, Comerford M, Liangpunsakul S, et al.
Dig Dis Sci . 2015 Jul; 60(12):3642-6. PMID: 26195313
Background And Aim: Hepatocyte apoptosis or necrosis from accumulation of bile salts may play an important role in the disease progression of primary sclerosing cholangitis (PSC). The aim of the...
4.
Liang T, Alloosh M, Bell L, Fullenkamp A, Saxena R, Van Alstine W, et al.
PLoS One . 2015 May; 10(5):e0124173. PMID: 25978364
Background: Ossabaw miniature swine when fed a diet high in fructose, saturated fat and cholesterol (NASH diet) develop metabolic syndrome and nonalcoholic steatohepatitis (NASH) characterized by liver injury and fibrosis....
5.
Willy J, Young S, Stevens J, Masuoka H, Wek R
Mol Biol Cell . 2015 Apr; 26(12):2190-204. PMID: 25904325
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the endoplasmic reticulum and activation of...
6.
Vuppalanchi R, Jain A, Deppe R, Yates K, Comerford M, Masuoka H, et al.
Clin Gastroenterol Hepatol . 2014 May; 12(12):2121-30.e1-2. PMID: 24846279
Background & Aims: Cross-sectional studies have associated serum levels of the keratin 18 (K18) fragment with histologic features of liver in individuals with nonalcoholic fatty liver disease (NAFLD). We investigated...
7.
Masuoka H, Chalasani N
Ann N Y Acad Sci . 2013 Feb; 1281:106-22. PMID: 23363012
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world and its incidence is increasing rapidly. NAFLD is a spectrum ranging from simple steatosis, which...
8.
Masuoka H, Rosen C
Clin Liver Dis . 2011 Oct; 15(4):699-715. PMID: 22032524
Cholangiocarcinoma (CCA) is a primary hepatic neoplasm that arises from malignant transformation of the biliary epithelium. Chronic biliary tree inflammation as occurs in primary sclerosing cholangitis (PSC) is a risk...
9.
Masuoka H, Rosen C
Clin Liver Dis . 2011 Jun; 15(2):385-93, vii-x. PMID: 21689620
Despite significant advances in nonsurgical treatments of hepatocellular carcinoma, these approaches rarely result in cure. Surgery remains the mainstay of curative therapy for hepatocellular carcinoma. Liver transplantation, in particular, has...
10.
Cazanave S, Mott J, Elmi N, Bronk S, Masuoka H, Charlton M, et al.
J Lipid Res . 2011 Jun; 52(8):1517-25. PMID: 21633093
Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in nonalcoholic fatty liver disease (NAFLD). Lipoapoptosis involves the upregulation of the BH3-only protein PUMA, a...