Hiroko Matsushita
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Explore the profile of Hiroko Matsushita including associated specialties, affiliations and a list of published articles.
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20
Citations
388
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Recent Articles
1.
Yoshida S, Hayakawa K, Oishi K, Mori S, Kanda T, Yamori Y, et al.
Radiology
. 2011 May;
260(2):511-20.
PMID: 21555354
Purpose: To evaluate the anatomy of deep gray and white matter structures in children with athetotic cerebral palsy (CP) and those with spastic CP by using diffusion-tensor (DT) imaging and...
2.
Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, et al.
Eur J Pharmacol
. 2009 Oct;
624(1-3):77-83.
PMID: 19836369
Melanin-concentrating hormone (MCH), which is a neuropeptide expressed in the hypothalamus of the brain, is involved in regulating feeding behavior and energy homeostasis via the MCH(1) receptor in rodents. It...
3.
Suzuki T, Kameda M, Ando M, Miyazoe H, Sekino E, Ito S, et al.
Bioorg Med Chem Lett
. 2009 Aug;
19(18):5339-45.
PMID: 19683441
Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity...
4.
Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, et al.
Bioorg Med Chem
. 2009 Jul;
17(16):6106-22.
PMID: 19616955
A series of 2-pyridone-containing imidazoline derivatives was synthesized and evaluated as neuropeptide Y Y5 receptor antagonists. Optimization of the 2-pyridone structure on the 2-position of the imidazoline ring led to...
5.
Mashiko S, Moriya R, Ishihara A, Gomori A, Matsushita H, Egashira S, et al.
Eur J Pharmacol
. 2009 Jun;
615(1-3):113-7.
PMID: 19482021
Neuropeptide Y plays a key role in the physiological control of energy homeostasis. Five neuropeptide Y receptor subtypes have been cloned, and multiple neuropeptide Y receptor subtypes are thought to...
6.
Ito M, Sakamoto T, Suzuki T, Egashira S, Moriya M, Ishihara A, et al.
Bioorg Med Chem Lett
. 2009 Apr;
19(10):2835-9.
PMID: 19361985
We have developed and characterized [(35)S]4a as a potent and selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R). Compound [(35)S]4a showed appreciable specific signals in brain slices prepared from wild-type mice...
7.
Matsushita H, Ishihara A, Mashiko S, Tanaka T, Kanno T, Iwaasa H, et al.
Endocrinology
. 2009 Feb;
150(6):2668-73.
PMID: 19196798
Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor-like 1 (ORL1), is involved in various central functions, such as pain, psychological stress, locomotor activity, learning and memory, and feeding regulation....
8.
Yoshida S, Hayakawa K, Yamamoto A, Aida N, Okano S, Matsushita H, et al.
Eur Radiol
. 2008 Sep;
19(2):462-9.
PMID: 18795297
The central tegmental tract (CTT) is mainly the extrapyramidal tract connecting between the red nucleus and the inferior olivary nucleus. There are only a few case reports describing CTT abnormalities...
9.
Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, et al.
Obesity (Silver Spring)
. 2008 Apr;
16(7):1510-5.
PMID: 18421274
Objective: To further address the function of the Y5 receptor in energy homeostasis, we investigated the effects of a novel spironolactone Y5 antagonist in diet-induced obese (DIO) mice. Methods And...
10.
Takahashi T, Matsushita H
J Music Ther
. 2007 Mar;
43(4):317-33.
PMID: 17348758
Over a period of 2 years we assessed the long-term effects of group music therapy carried out once weekly on the elderly (mean age: 83 years) suffering from moderate or...