Hilde Schjerven
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Explore the profile of Hilde Schjerven including associated specialties, affiliations and a list of published articles.
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24
Citations
840
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Recent Articles
1.
Podgorica M, Drivet E, Viken J, Richman A, Vestbostad J, Szodoray P, et al.
Eur J Haematol
. 2024 Jan;
112(5):731-742.
PMID: 38192186
Background: B-cell acute lymphoblastic leukemia (B-ALL) is classified into subgroups based on known driver oncogenes and molecular lesions, including translocations and recurrent mutations. However, the current diagnostic tests do not...
2.
Sin J, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, et al.
Sci Immunol
. 2023 Oct;
8(88):eabq3109.
PMID: 37889983
Mutations in the gene encoding the zinc-finger transcription factor Ikaros () are found in patients with immunodeficiency, leukemia, and autoimmunity. Although Ikaros has a well-established function in modulating gene expression...
3.
Cosgun K, Jumaa H, Robinson M, Kistner K, Xu L, Xiao G, et al.
bioRxiv
. 2023 Mar;
PMID: 36993619
Highlights: Unlike other cell lineages, B-cells express nuclear β-catenin protein at low baseline levels and depend on GSK3β for its degradation.In B-cells, β-catenin forms unique complexes with lymphoid-specific Ikaros factors...
4.
Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, et al.
Epigenomes
. 2022 Oct;
6(4).
PMID: 36278683
The hematopoietic transcription factor Ikaros () regulates normal B cell development and functions as a tumor suppressor in precursor B cell acute lymphoblastic leukemia (B-ALL). MicroRNAs (miRNAs) are small regulatory...
5.
Boyd J, Rodriguez P, Schjerven H, Frietze S
BMC Res Notes
. 2021 Sep;
14(1):366.
PMID: 34544495
Objective: Among the different methods to profile the genome-wide patterns of transcription factor binding and histone modifications in cells and tissues, CUT&RUN has emerged as a more efficient approach that...
6.
Rodriguez P, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S
Int J Mol Sci
. 2021 Apr;
22(5).
PMID: 33799946
Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding...
7.
Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd J, et al.
Sci Transl Med
. 2020 Jan;
12(526).
PMID: 31941829
Overcoming drug resistance remains a key challenge to cure patients with acute and chronic B cell malignancies. Here, we describe a stromal cell-autonomous signaling pathway, which contributes to drug resistance...
8.
Fistonich C, Zehentmeier S, Bednarski J, Miao R, Schjerven H, Sleckman B, et al.
J Exp Med
. 2018 Aug;
215(10):2586-2599.
PMID: 30158115
B cell progenitors require paracrine signals such as interleukin-7 (IL-7) provided by bone marrow stromal cells for proliferation and survival. Yet, how B cells regulate access to these signals in...
9.
Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al.
Nature
. 2018 Jun;
558(7711):E5.
PMID: 29849140
In Fig. 3c of this Letter, the the effects of CRISPR-Cas9-mediated deletion of NR3C1, TXNIP and CNR2 in patient-derived B-lineage leukaemia cells were shown. For curves depicting NR3C1 (left graph),...
10.
Van Nieuwenhove E, Garcia-Perez J, Helsen C, Rodriguez P, van Schouwenburg P, Dooley J, et al.
J Allergy Clin Immunol
. 2018 Apr;
142(2):699-702.e12.
PMID: 29705243
No abstract available.