Lai N Chan
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Explore the profile of Lai N Chan including associated specialties, affiliations and a list of published articles.
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28
Citations
908
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Recent Articles
1.
Chan A, Han L, Delaney C, Wang X, Mukhaleva E, Li M, et al.
Sci Adv
. 2024 Feb;
10(8):eadk3127.
PMID: 38394203
Epigenetic dysregulation has been reported in multiple cancers including leukemias. Nonetheless, the roles of the epigenetic reader Tudor domains in leukemia progression and therapy remain unexplored. Here, we conducted a...
2.
Samiksha S, Chan L
Haematologica
. 2023 Nov;
109(5):1317-1319.
PMID: 37916388
No abstract available.
3.
Li M, Yang L, Chan A, Pokharel S, Liu Q, Mattson N, et al.
Adv Sci (Weinh)
. 2023 Apr;
10(17):e2206584.
PMID: 37075745
Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS). However, the epigenetic networks underlying the maintenance of oncogenic signaling and therapeutic response remain unclear. Using a series of...
4.
Cosgun K, Jumaa H, Robinson M, Kistner K, Xu L, Xiao G, et al.
bioRxiv
. 2023 Mar;
PMID: 36993619
Highlights: Unlike other cell lineages, B-cells express nuclear β-catenin protein at low baseline levels and depend on GSK3β for its degradation.In B-cells, β-catenin forms unique complexes with lymphoid-specific Ikaros factors...
5.
Lee J, Robinson M, Sun R, Kume K, Ma N, Cosgun K, et al.
bioRxiv
. 2023 Mar;
PMID: 36993276
Initiation of B-cell receptor (BCR) signaling, and subsequent antigen-encounter in germinal centers represent milestones of B-lymphocyte development that are both marked by sharp increases of CD25 surface-expression. Oncogenic signaling in...
6.
Leveille E, Chan L, Mirza A, Kume K, Muschen M
Cell Signal
. 2022 Apr;
94:110331.
PMID: 35398488
SYK and ZAP70 nonreceptor tyrosine kinases serve essential roles in initiating B-cell receptor (BCR) and T-cell receptor (TCR) signaling in B- and T-lymphocytes, respectively. Despite their structural and functional similarity,...
7.
Contreras-Trujillo H, Eerdeng J, Akre S, Jiang D, Contreras J, Gala B, et al.
Nat Commun
. 2021 Nov;
12(1):6522.
PMID: 34764253
Cellular heterogeneity is a major cause of treatment resistance in cancer. Despite recent advances in single-cell genomic and transcriptomic sequencing, it remains difficult to relate measured molecular profiles to the...
8.
Chan L, Aghania E, Leveille E, Muschen M
Biochem Soc Trans
. 2021 Jul;
49(3):1467-1478.
PMID: 34196360
B-cells are antibody-producing cells of the adaptive immune system. Approximately 75% of all newly generated B-cells in the bone marrow are autoreactive and express potentially harmful autoantibodies. To prevent autoimmune...
9.
Lee J, Robinson M, Ma N, Artadji D, Ahmed M, Xiao G, et al.
Nature
. 2021 Mar;
592(7852):E3.
PMID: 33712811
No abstract available.
10.
Pan L, Hong C, Chan L, Xiao G, Malvi P, Robinson M, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(7).
PMID: 33531346
Unlike other cell types, developing B cells undergo multiple rounds of somatic recombination and hypermutation to evolve high-affinity antibodies. Reflecting the high frequency of DNA double-strand breaks, adaptive immune protection...