Hilde Schjerven
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Explore the profile of Hilde Schjerven including associated specialties, affiliations and a list of published articles.
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24
Citations
840
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Recent Articles
11.
Ye J, Qiu J, Bostick J, Ueda A, Schjerven H, Li S, et al.
Cell Rep
. 2017 Nov;
21(8):2277-2290.
PMID: 29166616
The local environment may affect the development and function of tissue-resident T regulatory cells (Tregs), which are crucial for controlling inflammation. Although the aryl hydrocarbon receptor (Ahr), an environmental sensor,...
12.
Katerndahl C, Heltemes-Harris L, Willette M, Henzler C, Frietze S, Yang R, et al.
Nat Immunol
. 2017 Apr;
18(6):694-704.
PMID: 28369050
The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked...
13.
Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al.
Nature
. 2017 Feb;
542(7642):479-483.
PMID: 28192788
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of...
14.
Schjerven H, Ayongaba E, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, et al.
J Exp Med
. 2017 Feb;
214(3):793-814.
PMID: 28190001
Inactivation of the tumor suppressor gene encoding the transcriptional regulator Ikaros () is a hallmark of BCR-ABL1 precursor B cell acute lymphoblastic leukemia (pre-B ALL). However, the mechanisms by which...
15.
Li S, Heller J, Bostick J, Lee A, Schjerven H, Kastner P, et al.
Immunity
. 2016 Jul;
45(1):185-97.
PMID: 27438771
Group 3 innate lymphoid cells (ILC3s) expressing the transcription factor (TF) RORγt are important for the defense and homeostasis of host intestinal tissues. The zinc finger TF Ikaros, encoded by...
16.
Arenzana T, Schjerven H, Smale S
Genes Dev
. 2015 Aug;
29(17):1801-16.
PMID: 26314708
The DNA-binding protein Ikaros is a potent tumor suppressor and hematopoietic regulator. However, the mechanisms by which Ikaros functions remain poorly understood, due in part to its atypical DNA-binding properties...
17.
Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan B, et al.
Blood
. 2015 Jul;
126(15):1813-22.
PMID: 26219304
Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros...
18.
Buchner M, Park E, Geng H, Klemm L, Flach J, Passegue E, et al.
Nat Commun
. 2015 Mar;
6:6471.
PMID: 25753524
Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for...
19.
Heller J, Schjerven H, Li S, Lee A, Qiu J, Chen Z, et al.
J Immunol
. 2014 Sep;
193(8):3934-46.
PMID: 25194055
Proper immune responses are needed to control pathogen infection at mucosal surfaces. IL-22-producing CD4(+) T cells play an important role in controlling bacterial infection in the gut; however, transcriptional regulation...
20.
Schjerven H, McLaughlin J, Arenzana T, Frietze S, Cheng D, Wadsworth S, et al.
Nat Immunol
. 2013 Sep;
14(10):1073-83.
PMID: 24013668
C2H2 zinc fingers are found in several key transcriptional regulators in the immune system. However, these proteins usually contain more fingers than are needed for sequence-specific DNA binding, which suggests...