Hieu T Van
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Explore the profile of Hieu T Van including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
137
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Recent Articles
1.
The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer
Nam C, Huang G, Zheng Y, Zhao H, Pan Y, Hu B, et al.
J Exp Med
. 2025 Feb;
222(4).
PMID: 39964485
Upper aerodigestive squamous cell carcinoma (UASCC) presents significant challenges in clinical management due to its aggressive nature. Here, we elucidate the role of MLL3 mutations as early, clonal genomic events...
2.
Van H, Xie G, Dong P, Liu Z, Ge K
J Mol Biol
. 2024 Jan;
436(7):168453.
PMID: 38266981
Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases are critical for gene regulation, cell differentiation, animal development, and human diseases. KMT2 biological roles are often attributed to their methyltransferase activities on lysine 4...
3.
Methyl-lysine readers PHF20 and PHF20L1 define two distinct gene expression-regulating NSL complexes
Van H, Harkins P, Patel A, Jain A, Lu Y, Bedford M, et al.
J Biol Chem
. 2022 Jan;
298(3):101588.
PMID: 35033534
The methyl-lysine readers plant homeodomain finger protein 20 (PHF20) and its homolog PHF20-like protein 1 (PHF20L1) are known components of the nonspecific lethal (NSL) complex that regulates gene expression through...
4.
Veazey K, Cheng D, Lin K, Villarreal O, Gao G, Perez-Oquendo M, et al.
Leukemia
. 2020 Jun;
34(12):3269-3285.
PMID: 32576962
Somatic mutations affecting CREBBP and EP300 are a hallmark of diffuse large B-cell lymphoma (DLBCL). These mutations are frequently monoallelic, within the histone acetyltransferase (HAT) domain and usually mutually exclusive,...
5.
Van H, Santos M
Cell Cycle
. 2018 Nov;
17(21-22):2399-2410.
PMID: 30394812
The timely and precise repair of DNA damage, or more specifically DNA double-strand breaks (DSBs) - the most deleterious DNA lesions, is crucial for maintaining genome integrity and cellular homeostasis....
6.
Caetano M, Hassane M, Van H, Bugarin E, Cumpian A, McDowell C, et al.
Nat Commun
. 2018 Nov;
9(1):4589.
PMID: 30389925
Lung adenocarcinomas (LUADs) with mutations in the K-ras oncogene display dismal prognosis. Proinflammatory and immunomodulatory events that drive development of K-ras mutant LUAD are poorly understood. Here, we develop a...
7.
Das P, Veazey K, Van H, Kaushik S, Lin K, Lu Y, et al.
Proc Natl Acad Sci U S A
. 2018 Oct;
115(43):E10137-E10146.
PMID: 30297393
The bone is essential for locomotion, calcium storage, and harboring the hematopoietic stem cells (HSCs) that supply the body with mature blood cells throughout life. HSCs reside at the interface...
8.
Tanaka N, Zhao M, Tang L, Patel A, Xi Q, Van H, et al.
Oncogene
. 2017 Dec;
37(10):1279-1292.
PMID: 29269868
Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that promote cancer cell invasive growth and metastasis, yet the mechanisms mediating these functions still largely remain elusive. We show here...