Andre Nussenzweig
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Explore the profile of Andre Nussenzweig including associated specialties, affiliations and a list of published articles.
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Articles
213
Citations
19127
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Recent Articles
1.
Wu L, Yadavalli A, Senigl F, Matos-Rodrigues G, Xu D, Pintado-Urbanc A, et al.
Mol Cell
. 2025 Mar;
PMID: 40049160
Somatic hypermutation (SHM) and class switch recombination (CSR) diversify immunoglobulin (Ig) genes and are initiated by the activation-induced deaminase (AID), a single-stranded DNA cytidine deaminase thought to engage its substrate...
2.
Fedkenheuer M, Shang Y, Jung S, Fedkenheuer K, Park S, Mazza D, et al.
Nat Commun
. 2025 Jan;
16(1):843.
PMID: 39833168
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental...
3.
Gerhart B, Pellerin D, Danzi M, Zuchner S, Brais B, Matos-Rodrigues G, et al.
Neurol Genet
. 2024 Nov;
10(6):e200210.
PMID: 39574782
Background And Objectives: The number of GAA repeats in the gene is a major but not sole determinant of the clinical presentation of Friedreich ataxia (FRDA). The objective of this...
4.
Scully R, Walter J, Nussenzweig A
DNA Repair (Amst)
. 2024 Nov;
144:103783.
PMID: 39504607
Replisome collision with a nicked parental DNA template can lead to the formation of a replication-associated double strand break (DSB). How this break is repaired has implications for cancer initiation,...
5.
Chen B, Pham T, Reynolds L, Dang N, Zhang Y, Manalang K, et al.
bioRxiv
. 2024 Oct;
PMID: 39386666
Non-homologous end joining (NHEJ) is required for repairing DNA double strand breaks (DSBs) generated by the RAG endonuclease during lymphocyte antigen receptor gene assembly by V(D)J recombination. The Ataxia telangiectasia...
6.
Wu L, Yadavalli A, Matos-Rodrigues G, Xu D, Pintado-Urbanc A, Simon M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386505
Somatic hypermutation (SHM) and class switch recombination (CSR) diversify immunoglobulin (Ig) genes and are initiated by the activation induced deaminase (AID), a single-stranded DNA cytidine deaminase that is thought to...
7.
Pellerin D, Mereaux J, Boluda S, Danzi M, Dicaire M, Davoine C, et al.
Brain
. 2024 Oct;
PMID: 39378335
Spinocerebellar ataxia 27B (SCA27B) is a common autosomal dominant ataxia caused by an intronic GAA•TTC repeat expansion in FGF14. Neuropathological studies have shown that neuronal loss is largely restricted to...
8.
Pellerin D, Mereaux J, Boluda S, Danzi M, Dicaire M, Davoine C, et al.
medRxiv
. 2024 Jul;
PMID: 39006414
Spinocerebellar ataxia 27B (SCA27B) is a common autosomal dominant ataxia caused by an intronic GAA•TTC repeat expansion in . Neuropathological studies have shown that neuronal loss is largely restricted to...
9.
Reginato G, Dello Stritto M, Wang Y, Hao J, Pavani R, Schmitz M, et al.
Nat Commun
. 2024 Jul;
15(1):5789.
PMID: 38987539
The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed repair (HDR) of protein-blocked DSBs requires DNA end resection that is...
10.
Ramadoss G, Namaganda S, Hamilton J, Sharma R, Chow K, Macklin B, et al.
bioRxiv
. 2024 Jul;
PMID: 38979269
Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing...