Histone Modifications and the DNA Double-strand Break Response

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2018 Nov 6

PMID 30394812

Citations 28

Authors

Hieu T Van

Margarida A Santos

Affiliations

Soon will be listed here.

Abstract

The timely and precise repair of DNA damage, or more specifically DNA double-strand breaks (DSBs) - the most deleterious DNA lesions, is crucial for maintaining genome integrity and cellular homeostasis. An appropriate cellular response to DNA DSBs requires the integration of various factors, including the post-translational modifications (PTMs) of chromatin and chromatin-associated proteins. Notably, the PTMs of histones have been shown to play a fundamental role in initiating and regulating cellular responses to DNA DSBs. Here we review the role of the major histone PTMs, including phosphorylation, ubiquitination, methylation and acetylation, and their interactions during DNA DSB-induced responses.

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References

Chowdhury D, Keogh M, Ishii H, Peterson C, Buratowski S, Lieberman J . gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell. 2005; 20(5):801-9. DOI: 10.1016/j.molcel.2005.10.003. View

Jackson S, Bartek J . The DNA-damage response in human biology and disease. Nature. 2009; 461(7267):1071-8. PMC: 2906700. DOI: 10.1038/nature08467. View

Krishnan S, Horowitz S, Trievel R . Structure and function of histone H3 lysine 9 methyltransferases and demethylases. Chembiochem. 2011; 12(2):254-63. DOI: 10.1002/cbic.201000545. View

Martin M, Terradas M, Hernandez L, Genesca A . γH2AX foci on apparently intact mitotic chromosomes: not signatures of misrejoining events but signals of unresolved DNA damage. Cell Cycle. 2014; 13(19):3026-36. PMC: 4614418. DOI: 10.4161/15384101.2014.947786. View

Stewart G, Panier S, Townsend K, Al-Hakim A, Kolas N, Miller E . The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell. 2009; 136(3):420-34. DOI: 10.1016/j.cell.2008.12.042. View

Iacovoni J, Caron P, Lassadi I, Nicolas E, Massip L, Trouche D . High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J. 2010; 29(8):1446-57. PMC: 2868577. DOI: 10.1038/emboj.2010.38. View

Li B, Carey M, Workman J . The role of chromatin during transcription. Cell. 2007; 128(4):707-19. DOI: 10.1016/j.cell.2007.01.015. View

Masumoto H, Hawke D, Kobayashi R, Verreault A . A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature. 2005; 436(7048):294-8. DOI: 10.1038/nature03714. View

Vempati R, Jayani R, Notani D, Sengupta A, Galande S, Haldar D . p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals. J Biol Chem. 2010; 285(37):28553-64. PMC: 2937881. DOI: 10.1074/jbc.M110.149393. View

10.

Ayrapetov M, Gursoy-Yuzugullu O, Xu C, Xu Y, Price B . DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc Natl Acad Sci U S A. 2014; 111(25):9169-74. PMC: 4078803. DOI: 10.1073/pnas.1403565111. View

11.

Wu J, Huen M, Lu L, Ye L, Dou Y, Ljungman M . Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol. 2008; 29(3):849-60. PMC: 2630672. DOI: 10.1128/MCB.01302-08. View

12.

Sulli G, Di Micco R, dAdda di Fagagna F . Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer. Nat Rev Cancer. 2012; 12(10):709-20. DOI: 10.1038/nrc3344. View

13.

OCarroll D, Scherthan H, Peters A, Opravil S, Haynes A, Laible G . Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol Cell Biol. 2000; 20(24):9423-33. PMC: 102198. DOI: 10.1128/MCB.20.24.9423-9433.2000. View

14.

Bonner W, Redon C, Dickey J, Nakamura A, Sedelnikova O, Solier S . GammaH2AX and cancer. Nat Rev Cancer. 2008; 8(12):957-67. PMC: 3094856. DOI: 10.1038/nrc2523. View

15.

Paull T, Rogakou E, Yamazaki V, Kirchgessner C, Gellert M, Bonner W . A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000; 10(15):886-95. DOI: 10.1016/s0960-9822(00)00610-2. View

16.

Das C, Lucia M, Hansen K, Tyler J . CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature. 2009; 459(7243):113-7. PMC: 2756583. DOI: 10.1038/nature07861. View

17.

Matsuoka S, Ballif B, Smogorzewska A, McDonald 3rd E, Hurov K, Luo J . ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007; 316(5828):1160-6. DOI: 10.1126/science.1140321. View

18.

Gupta A, Sharma G, Young C, Agarwal M, Smith E, Paull T . Involvement of human MOF in ATM function. Mol Cell Biol. 2005; 25(12):5292-305. PMC: 1140595. DOI: 10.1128/MCB.25.12.5292-5305.2005. View

19.

Dasika G, Lin S, Zhao S, Sung P, Tomkinson A, Lee E . DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene. 2000; 18(55):7883-99. DOI: 10.1038/sj.onc.1203283. View

20.

Cheung W, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen C . Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003; 113(4):507-17. DOI: 10.1016/s0092-8674(03)00355-6. View