Heinz Ruffner
Overview
Explore the profile of Heinz Ruffner including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
23
Citations
3442
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Namoto K, Baader C, Orsini V, Landshammer A, Breuer E, Dinh K, et al.
Cell Stem Cell
. 2024 Apr;
31(4):554-569.e17.
PMID: 38579685
The YAP/Hippo pathway is an organ growth and size regulation rheostat safeguarding multiple tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate YAP, thus representing a potential direct drug...
2.
Richards S, Gubser Keller C, Kreutzer R, Greiner G, Ley S, Doelemeyer A, et al.
Int Wound J
. 2023 Dec;
21(4):e14447.
PMID: 38149752
A limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various...
3.
Saponara E, Penno C, Orsini V, Wang Z, Fischer A, Aebi A, et al.
Am J Pathol
. 2022 Nov;
193(2):161-181.
PMID: 36410420
The roof plate-specific spondin-leucine-rich repeat-containing G-protein coupled receptor 4/5 (LGR4/5)-zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic...
4.
Sun T, Annunziato S, Bergling S, Sheng C, Orsini V, Forcella P, et al.
Cell Stem Cell
. 2021 Jun;
28(10):1822-1837.e10.
PMID: 34129813
AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show low proliferation rates despite a WNT/β-Catenin activity gradient...
5.
Schutzius G, Kolter C, Bergling S, Tortelli F, Fuchs F, Renner S, et al.
Nat Chem Biol
. 2021 Jan;
17(3):280-290.
PMID: 33462494
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal...
6.
Sun T, Pikiolek M, Orsini V, Bergling S, Holwerda S, Morelli L, et al.
Cell Stem Cell
. 2019 Dec;
26(1):97-107.e6.
PMID: 31866224
The existence of specialized liver stem cell populations, including AXIN2 pericentral hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using AXIN2 lineage tracing in BAC-transgenic mice, we confirm...
7.
Mercado N, Schutzius G, Kolter C, Estoppey D, Bergling S, Roma G, et al.
Nat Commun
. 2019 Oct;
10(1):4676.
PMID: 31611556
Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting...
8.
Gauthier A, Fisch A, Seuwen K, Baumgarten B, Ruffner H, Aebi A, et al.
Biomaterials
. 2018 Apr;
178:481-495.
PMID: 29650255
Glucocorticoids are well established anti-inflammatory agents, however, their use to treat chronic inflammatory diseases is limited due to a number of serious side effects. For example, long-term local treatment of...
9.
Ley S, Galuba O, Salathe A, Melin N, Aebi A, Pikiolek M, et al.
SLAS Discov
. 2017 Mar;
22(5):571-582.
PMID: 28345372
Oral and intestinal mucositis is a debilitating side effect of radiation treatment. A mouse model of radiation-induced mucositis leads to weight loss and tissue damage, reflecting the human ailment as...
10.
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F, et al.
Nat Cell Biol
. 2016 Oct;
18(11):1260.
PMID: 27784900
No abstract available.