Tewis Bouwmeester
Overview
Explore the profile of Tewis Bouwmeester including associated specialties, affiliations and a list of published articles.
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63
Citations
7972
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Recent Articles
1.
Ting P, Borikar S, Kerrigan J, Thomsen N, Aghania E, Hinman A, et al.
Science
. 2024 Jul;
385(6704):91-99.
PMID: 38963839
Sickle cell disease (SCD) is a prevalent, life-threatening condition attributable to a heritable mutation in β-hemoglobin. Therapeutic induction of fetal hemoglobin (HbF) can ameliorate disease complications and has been intently...
2.
Namoto K, Baader C, Orsini V, Landshammer A, Breuer E, Dinh K, et al.
Cell Stem Cell
. 2024 Apr;
31(4):554-569.e17.
PMID: 38579685
The YAP/Hippo pathway is an organ growth and size regulation rheostat safeguarding multiple tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate YAP, thus representing a potential direct drug...
3.
Richards S, Gubser Keller C, Kreutzer R, Greiner G, Ley S, Doelemeyer A, et al.
Int Wound J
. 2023 Dec;
21(4):e14447.
PMID: 38149752
A limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various...
4.
Saponara E, Penno C, Orsini V, Wang Z, Fischer A, Aebi A, et al.
Am J Pathol
. 2022 Nov;
193(2):161-181.
PMID: 36410420
The roof plate-specific spondin-leucine-rich repeat-containing G-protein coupled receptor 4/5 (LGR4/5)-zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic...
5.
Kruttner S, Falasconi A, Valbuena S, Galimberti I, Bouwmeester T, Arber S, et al.
Neuron
. 2022 Feb;
110(9):1468-1482.e5.
PMID: 35219402
Autism spectrum disorder (ASD) involves genetic and environmental components. The underlying circuit mechanisms are unclear, but behaviorally, aversion toward unfamiliarity, a hallmark of autism, might be involved. Here, we show...
6.
Estoppey D, Schutzius G, Kolter C, Salathe A, Wunderlin T, Meyer A, et al.
iScience
. 2021 Nov;
24(11):103323.
PMID: 34805786
BET bromodomain inhibitors hold promise as therapeutic agents in diverse indications, but their clinical progression has been challenging and none have received regulatory approval. Early clinical trials in cancer have...
7.
Sun T, Annunziato S, Bergling S, Sheng C, Orsini V, Forcella P, et al.
Cell Stem Cell
. 2021 Jun;
28(10):1822-1837.e10.
PMID: 34129813
AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show low proliferation rates despite a WNT/β-Catenin activity gradient...
8.
Fustinana M, Eichlisberger T, Bouwmeester T, Bitterman Y, Luthi A
Nature
. 2021 Mar;
592(7853):267-271.
PMID: 33658711
The behaviour of an animal is determined by metabolic, emotional and social factors. Depending on its state, an animal will focus on avoiding threats, foraging for food or on social...
9.
Schutzius G, Kolter C, Bergling S, Tortelli F, Fuchs F, Renner S, et al.
Nat Chem Biol
. 2021 Jan;
17(3):280-290.
PMID: 33462494
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal...
10.
Huang K, Rupprecht P, Frank T, Kawakami K, Bouwmeester T, Friedrich R
Nat Methods
. 2020 Mar;
17(3):343-351.
PMID: 32123394
Virtual realities are powerful tools to analyze and manipulate interactions between animals and their environment and to enable measurements of neuronal activity during behavior. In many species, however, optical access...