Florian Nigsch
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Explore the profile of Florian Nigsch including associated specialties, affiliations and a list of published articles.
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49
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1384
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Recent Articles
1.
Steinhauser S, Estoppey D, Buehler D, Xiong Y, Pizzato N, Rietsch A, et al.
JCI Insight
. 2025 Feb;
PMID: 39998893
Metabolic dysfunction-associated steatotic liver disease (MASLD)-characterized by excess accumulation of fat in the liver-now affects one third of the world's population. As MASLD progresses, extracellular matrix components including collagen accumulate...
2.
Yin J, Frick L, Scheidmann M, Liu T, Trevisan C, Dhingra A, et al.
Nat Biomed Eng
. 2024 Dec;
9(1):127-148.
PMID: 39633028
Arrayed CRISPR libraries extend the scope of gene-perturbation screens to non-selectable cell phenotypes. However, library generation requires assembling thousands of vectors expressing single-guide RNAs (sgRNAs). Here, by leveraging massively parallel...
3.
Mutlu M, Schmidt I, Morrison A, Goretzki B, Freuler F, Begue D, et al.
Nat Commun
. 2024 May;
15(1):4584.
PMID: 38811577
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its...
4.
Steinhauser S, Estoppey D, Buehler D, Xiong Y, Pizzato N, Rietsch A, et al.
bioRxiv
. 2024 May;
PMID: 38712281
Non-alcoholic fatty liver disease (NAFLD) - characterized by excess accumulation of fat in the liver - now affects one third of the world's population. As NAFLD progresses, extracellular matrix components...
5.
Li J, Moretti F, Hidvegi T, Sviben S, Fitzpatrick J, Sundaramoorthi H, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Feb;
17(6):1007-1024.
PMID: 38336172
Background & Aims: In the classic form of α1-antitrypsin deficiency (ATD), the misfolded α1-antitrypsin Z (ATZ) variant accumulates in the endoplasmic reticulum (ER) of liver cells. A gain-of-function proteotoxic mechanism...
6.
Richards S, Guo F, Zou H, Nigsch F, Baiges A, Pachori A, et al.
Liver Int
. 2023 Jul;
43(9):1984-1994.
PMID: 37443448
Background And Aims: A reduction in hepatic venous pressure gradient (HVPG) is the most accurate marker for assessing the severity of portal hypertension and the effectiveness of intervention treatments. This...
7.
Welte T, Goulois A, Stadler M, Hess D, Soneson C, Neagu A, et al.
Mol Cell
. 2023 Jun;
83(14):2478-2492.e8.
PMID: 37369201
The RNA-binding protein TRIM71/LIN-41 is a phylogenetically conserved developmental regulator that functions in mammalian stem cell reprogramming, brain development, and cancer. TRIM71 recognizes target mRNAs through hairpin motifs and silences...
8.
Saponara E, Penno C, Orsini V, Wang Z, Fischer A, Aebi A, et al.
Am J Pathol
. 2022 Nov;
193(2):161-181.
PMID: 36410420
The roof plate-specific spondin-leucine-rich repeat-containing G-protein coupled receptor 4/5 (LGR4/5)-zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic...
9.
Ungricht R, Guibbal L, Lasbennes M, Orsini V, Beibel M, Waldt A, et al.
Cell Stem Cell
. 2021 Nov;
29(1):160-175.e7.
PMID: 34847364
Human organoids allow the study of proliferation, lineage specification, and 3D tissue development. Here we present a genome-wide CRISPR screen in induced pluripotent stem cell (iPSC)-derived kidney organoids. The combination...
10.
Estoppey D, Schutzius G, Kolter C, Salathe A, Wunderlin T, Meyer A, et al.
iScience
. 2021 Nov;
24(11):103323.
PMID: 34805786
BET bromodomain inhibitors hold promise as therapeutic agents in diverse indications, but their clinical progression has been challenging and none have received regulatory approval. Early clinical trials in cancer have...