Sebastian Bergling
Overview
Explore the profile of Sebastian Bergling including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
879
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Recent Articles
1.
Steinhauser S, Estoppey D, Buehler D, Xiong Y, Pizzato N, Rietsch A, et al.
JCI Insight
. 2025 Feb;
PMID: 39998893
Metabolic dysfunction-associated steatotic liver disease (MASLD)-characterized by excess accumulation of fat in the liver-now affects one third of the world's population. As MASLD progresses, extracellular matrix components including collagen accumulate...
2.
Steinhauser S, Estoppey D, Buehler D, Xiong Y, Pizzato N, Rietsch A, et al.
bioRxiv
. 2024 May;
PMID: 38712281
Non-alcoholic fatty liver disease (NAFLD) - characterized by excess accumulation of fat in the liver - now affects one third of the world's population. As NAFLD progresses, extracellular matrix components...
3.
Bier K, Senajova Z, Henrion F, Wang Y, Bruno S, Rauld C, et al.
J Invest Dermatol
. 2024 Jan;
144(7):1544-1556.e9.
PMID: 38237730
Atopic dermatitis (AD) is a debilitating inflammatory skin disorder. Biologics targeting the IL-4/IL-13 axis are effective in AD, but there is still a large proportion of patients who do not...
4.
Sun T, Annunziato S, Bergling S, Sheng C, Orsini V, Forcella P, et al.
Cell Stem Cell
. 2021 Jun;
28(10):1822-1837.e10.
PMID: 34129813
AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show low proliferation rates despite a WNT/β-Catenin activity gradient...
5.
Schutzius G, Kolter C, Bergling S, Tortelli F, Fuchs F, Renner S, et al.
Nat Chem Biol
. 2021 Jan;
17(3):280-290.
PMID: 33462494
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal...
6.
Dafflon C, Gaulis S, Barys L, Kapur K, Cornacchione V, Schukur L, et al.
Oncotarget
. 2020 Mar;
11(11):956-968.
PMID: 32215184
The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of -rearranged leukemia. Serendipitous observations during high-throughput drug screens indicated...
7.
Sun T, Pikiolek M, Orsini V, Bergling S, Holwerda S, Morelli L, et al.
Cell Stem Cell
. 2019 Dec;
26(1):97-107.e6.
PMID: 31866224
The existence of specialized liver stem cell populations, including AXIN2 pericentral hepatocytes, that safeguard homeostasis and repair has been controversial. Here, using AXIN2 lineage tracing in BAC-transgenic mice, we confirm...
8.
Mercado N, Schutzius G, Kolter C, Estoppey D, Bergling S, Roma G, et al.
Nat Commun
. 2019 Oct;
10(1):4676.
PMID: 31611556
Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting...
9.
Calabrese D, Roma G, Bergling S, Carbone W, Mele V, Nuciforo S, et al.
PLoS One
. 2019 Aug;
14(8):e0221762.
PMID: 31465481
Background & Aims: Hepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iPSCs) have emerged as a promising cell culture model to study metabolism, biotransformation, viral infections and inherited liver...
10.
Planas-Paz L, Sun T, Pikiolek M, Cochran N, Bergling S, Orsini V, et al.
Cell Stem Cell
. 2019 May;
25(1):39-53.e10.
PMID: 31080135
Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells that establish a ductular reaction (DR) to support liver regeneration following injury. Liver damage...