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Heberth de Paula

Explore the profile of Heberth de Paula including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 89
Followers 0
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Recent Articles
1.
de Paula H, Bolsoni C, de Souza F, da Rocha Fonseca V, Romao W, de Sairre M, et al.
Chem Biol Drug Des . 2024 Nov; 104(5):e70016. PMID: 39543966
Type 2 diabetes mellitus is a dramatically increasing global public health challenge. The prevalence is projected almost double, from 194 million in 2003 to 333 million in 2025 with type...
2.
Morais P, Britto K, Messias E, de Andrade P, Werner E, Vidal Costa A, et al.
J Agric Food Chem . 2022 Dec; 71(1):255-266. PMID: 36583683
Concerned about weed infestation, a major threat to food production and herbicide resistance that interferes in the mechanism of action of the main herbicides, we have synthesized eight isatin derivatives...
3.
Pantaleao S, Philot E, de Paula H, de Sairre M, Lima A, Pires L, et al.
Biochimie . 2021 Dec; 194:43-50. PMID: 34952193
Diabetes is a metabolic disorder that presents hyperglycemia and vascular complications due to the non-production of insulin or its inappropriate use by the body. One of the strategies to treat...
4.
de Paula H, Angelo R, Honorio K
J Mol Model . 2021 Aug; 27(9):239. PMID: 34363097
Protein kinases (in this case, HER-2 and EGFR) are involved in cancer-related diseases. Some reports have shown unique CoMFA models using the sum of activities expressed as pIC (-log IC),...
5.
Ribeiro R, Eloy M, Francisco C, Javarini C, Ayusso G, da Rocha Fonseca V, et al.
Curr Top Med Chem . 2021 Jul; 21(22):1999-2017. PMID: 34225623
Background: Natural products have been universally approached in the research of novel trends useful to detail the essential paths of the life sciences and as a strategy for pharmacotherapeutics. Objective:...
6.
Conti C, Borcoi A, Almanca C, Barbosa W, Archanjo A, de Assis Pinheiro J, et al.
Community Ment Health J . 2020 May; 56(7):1292-1297. PMID: 32451795
This study aimed to investigate the risk factors for depressive symptoms among rural residents in Brazil. A representative sample of two hundred eighty-eight volunteers aged from 18 to 65 years...
7.
Zaki P, Domingues E, Amjad F, Narde M, Goncalves K, Viana M, et al.
Parasitol Res . 2020 Apr; 119(6):1845. PMID: 32307581
The authors regret that Philipp E Scherer's name was spelt incorrectly in the author list. The name of the author is now corrected above.
8.
Zaki P, Domingues E, Amjad F, Narde M, Goncalves K, Viana M, et al.
Parasitol Res . 2020 Mar; 119(6):1829-1843. PMID: 32206887
The underlying pathogenic mechanisms of cardiomyopathy in Chagas disease are still unsolved. In order to better clarify the role of fat on the evolution of cardiomyopathy, the present study employed...
9.
Francisco C, Javarini C, de S Barcelos I, Morais P, de Paula H, Borges W, et al.
Curr Top Med Chem . 2019 Oct; 20(2):153-160. PMID: 31648640
Background: Glycogen synthase kinase-3 (GSK-3) is involved in the phosphorylation and inactivation of glycogen synthase. GSK-3 inhibitors have been associated with a variety of diseases, including Alzheimer´s disease (AD), diabetes...
10.
de Angelo R, de Oliveira Almeida M, de Paula H, Honorio K
Int J Mol Sci . 2018 Nov; 19(12). PMID: 30477154
HER-2 and EGFR are biological targets related to the development of cancer and the discovery and/or development of a dual inhibitor could be a good strategy to design an effective...