Heather Sadlish
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Explore the profile of Heather Sadlish including associated specialties, affiliations and a list of published articles.
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12
Citations
540
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Recent Articles
1.
Choi J, Kii H, Nelson J, Yamazaki Y, Yanagawa F, Kitajima A, et al.
SLAS Technol
. 2022 Dec;
28(2):63-69.
PMID: 36455858
The development of phenotypic assays with appropriate analyses is an important step in the drug discovery process. Assays using induced pluripotent stem cell (iPSC)-derived human neurons are emerging as powerful...
2.
Vincent B, Tardiff D, Piotrowski J, Aron R, Lucas M, Chung C, et al.
Cell Rep
. 2018 Dec;
25(10):2742-2754.e31.
PMID: 30517862
The lack of disease-modifying treatments for neurodegenerative disease stems in part from our rudimentary understanding of disease mechanisms and the paucity of targets for therapeutic intervention. Here we used an...
3.
Hassan A, Kirby C, Zhou W, Schuhmann T, Kityk R, Kipp D, et al.
Chem Biol
. 2014 Dec;
22(1):87-97.
PMID: 25544045
The highly conserved 70 kDa heat shock proteins (Hsp70) play an integral role in proteostasis such that dysregulation has been implicated in numerous diseases. Elucidating the precise role of Hsp70...
4.
Hoepfner D, Helliwell S, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, et al.
Microbiol Res
. 2013 Dec;
169(2-3):107-20.
PMID: 24360837
Due to evolutionary conservation of biology, experimental knowledge captured from genetic studies in eukaryotic model organisms provides insight into human cellular pathways and ultimately physiology. Yeast chemogenomic profiling is a...
5.
Sadlish H, Galicia-Vazquez G, Paris C, Aust T, Bhullar B, Chang L, et al.
ACS Chem Biol
. 2013 Apr;
8(7):1519-27.
PMID: 23614532
Translation initiation is an emerging target in oncology and neurobiology indications. Naturally derived and synthetic rocaglamide scaffolds have been used to interrogate this pathway; however, there is uncertainty regarding their...
6.
Sadlish H, Rampelt H, Shorter J, Wegrzyn R, Andreasson C, Lindquist S, et al.
PLoS One
. 2008 Mar;
3(3):e1763.
PMID: 18335038
The cytosolic chaperone network of Saccharomyces cerevisiae is intimately associated with the emergence and maintenance of prion traits. Recently, the Hsp110 protein, Sse1, has been identified as a nucleotide exchange...
7.
Raviol H, Sadlish H, Rodriguez F, Mayer M, Bukau B
EMBO J
. 2006 May;
25(11):2510-8.
PMID: 16688211
The Hsp110 proteins, exclusively found in the eukaryotic cytosol, have significant sequence homology to the Hsp70 molecular chaperone superfamily. Despite this homology and the cellular abundance of these proteins, the...
8.
Sadlish H, Pitonzo D, Johnson A, Skach W
Nat Struct Mol Biol
. 2005 Sep;
12(10):870-8.
PMID: 16186821
During polytopic protein biogenesis, the Sec61 translocon must rapidly orient and integrate multiple transmembrane segments (TMs) into the endoplasmic reticulum membrane. To understand this process, we examined interactions between Sec61alpha...
9.
Flintoff W, Sadlish H, Gorlick R, Yang R, Williams F
Biochim Biophys Acta
. 2004 Oct;
1690(2):110-7.
PMID: 15469899
Osteosarcomas are common primary malignant bone tumors that do not respond to conventional low-dose treatments of methotrexate (Mtx), suggesting an intrinsic resistance to this drug. Previous work has shown that...
10.
Flintoff W, Williams F, Sadlish H
J Biol Chem
. 2003 Aug;
278(42):40867-76.
PMID: 12909642
A functional cysteine-less form of the hamster reduced folate carrier protein was generated by alanine replacement of the 14 cysteine residues. The predicted 12-transmembrane topology was examined by replacing selected...