Stephen B Helliwell
Overview
Explore the profile of Stephen B Helliwell including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
1014
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Shimada K, Tarashev C, Bregenhorn S, Gerhold C, van Loon B, Roth G, et al.
Nat Commun
. 2024 Nov;
15(1):9908.
PMID: 39548071
Combinational therapies provoking cell death are of major interest in oncology. Combining TORC2 kinase inhibition with the radiomimetic drug Zeocin results in a rapid accumulation of double-strand breaks (DSB) in...
2.
Hurst V, Gerhold C, Tarashev C, Challa K, Seeber A, Yamazaki S, et al.
Nat Commun
. 2024 Nov;
15(1):9910.
PMID: 39548059
Loss of cytosolic actin filaments upon TORC2 inhibition triggers chromosome fragmentation in yeast, which results from altered base excision repair of Zeocin-induced lesions. To find the link between TORC2 kinase...
3.
Boekstein N, Barzilai N, Bertram A, Betts-LaCroix J, Fortney K, Helliwell S, et al.
Nat Biotechnol
. 2023 Jun;
41(8):1053-1055.
PMID: 37365260
No abstract available.
4.
Wang Z, Keogh A, Waldt A, Cuttat R, Neri M, Zhu S, et al.
Sci Rep
. 2021 Sep;
11(1):19396.
PMID: 34588551
Fibrosis is characterized by the excessive production of collagen and other extracellular matrix (ECM) components and represents a leading cause of morbidity and mortality worldwide. Previous studies of nonalcoholic steatohepatitis...
5.
Snyder N, Kim A, Kester L, Gale A, Studer C, Hoepfner D, et al.
G3 (Bethesda)
. 2019 Jan;
9(3):829-840.
PMID: 30670608
Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful...
6.
Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell S, Prouteau M, et al.
J Biol Chem
. 2018 Jun;
293(31):12043-12053.
PMID: 29895620
Target of rapamycin complex 2 (TORC2) is a widely conserved serine/threonine protein kinase. In the yeast , TORC2 is essential, playing a key role in plasma membrane homeostasis. In this...
7.
Russell O, Fruh I, Rai P, Marcellin D, Doll T, Reeve A, et al.
Sci Rep
. 2018 Jan;
8(1):1799.
PMID: 29379065
We generated induced pluripotent stem cells (iPSCs) from patient fibroblasts to yield cell lines containing varying degrees of heteroplasmy for a m.13514 A > G mtDNA point mutation (2 lines)...
8.
Potting C, Crochemore C, Moretti F, Nigsch F, Schmidt I, Manneville C, et al.
Proc Natl Acad Sci U S A
. 2017 Dec;
115(2):E180-E189.
PMID: 29269392
PARKIN, an E3 ligase mutated in familial Parkinson's disease, promotes mitophagy by ubiquitinating mitochondrial proteins for efficient engagement of the autophagy machinery. Specifically, PARKIN-synthesized ubiquitin chains represent targets for the...
9.
Filipuzzi I, Steffen J, Germain M, Goepfert L, Conti M, Potting C, et al.
Nat Chem Biol
. 2017 Oct;
13(12):1239-1244.
PMID: 28991239
Tim17 and Tim23 are the main subunits of the TIM23 complex, one of the two major essential mitochondrial inner-membrane protein translocon machineries (TIMs). No chemical probes that specifically inhibit TIM23-dependent...
10.
Petrovic K, Pfeifer M, Parker C, Schuierer S, Tallarico J, Hoepfner D, et al.
Microbiol Res
. 2017 Apr;
199:10-18.
PMID: 28454705
The budding yeast S. cerevisiae is widely used as a eukaryotic model organism to elucidate the mechanism of action of low molecular weight compounds. This report describes the development of...