Harm-Jan Westra
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Explore the profile of Harm-Jan Westra including associated specialties, affiliations and a list of published articles.
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86
Citations
17325
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Recent Articles
1.
Demirkan A, Dongen J, Finnicum C, Westra H, Jankipersadsing S, Willemsen G, et al.
BMC Genomics
. 2024 Dec;
25(1):1224.
PMID: 39702006
Microbiome influences multiple human systems, but its effects on gene methylation is unknown. We investigated the relations between gene methylation in blood and the abundance of common gut bacteria profiled...
2.
Bakker O, Claringbould A, Westra H, Wiersma H, Boulogne F, Vosa U, et al.
Sci Rep
. 2024 Dec;
14(1):30206.
PMID: 39632930
Genetic variants identified through genome-wide association studies (GWAS) are typically non-coding, exerting small regulatory effects on downstream genes. However, which downstream genes are ultimately impacted and how they confer risk...
3.
Wu J, Palasantzas V, Andreu-Sanchez S, Plosch T, Leonard S, Li S, et al.
Clin Epigenetics
. 2024 Aug;
16(1):104.
PMID: 39138531
Background: The plasma metabolome reflects the physiological state of various biological processes and can serve as a proxy for disease risk. Plasma metabolite variation, influenced by genetic and epigenetic mechanisms,...
4.
Urzua-Traslavina C, van Lieshout T, Boulogne F, Domanegg K, Zidan M, Bakker O, et al.
BMC Med Genomics
. 2024 Jul;
17(1):186.
PMID: 39010058
Background: The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of...
5.
Kim T, Martinez-Bonet M, Wang Q, Hackert N, Sparks J, Baglaenko Y, et al.
Nat Commun
. 2024 Mar;
15(1):2150.
PMID: 38459032
Fine-mapping and functional studies implicate rs117701653, a non-coding single nucleotide polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and type 1 diabetes. Here, using DNA pulldown,...
6.
Vochteloo M, Deelen P, Vink B, Tsai E, Runz H, Andreu-Sanchez S, et al.
Genome Biol
. 2024 Jan;
25(1):29.
PMID: 38254182
Expression quantitative trait loci (eQTL) offer insights into the regulatory mechanisms of trait-associated variants, but their effects often rely on contexts that are unknown or unmeasured. We introduce PICALO, a...
7.
Li S, Schmid K, de Vries D, Korshevniuk M, Losert C, Oelen R, et al.
Genome Biol
. 2023 Apr;
24(1):80.
PMID: 37072791
Background: Expression quantitative trait loci (eQTL) studies show how genetic variants affect downstream gene expression. Single-cell data allows reconstruction of personalized co-expression networks and therefore the identification of SNPs altering...
8.
de Klein N, Tsai E, Vochteloo M, Baird D, Huang Y, Chen C, et al.
Nat Genet
. 2023 Feb;
55(3):377-388.
PMID: 36823318
Identification of therapeutic targets from genome-wide association studies (GWAS) requires insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing samples from 14 brain datasets to create the MetaBrain resource and...
9.
Boulogne F, Claus L, Wiersma H, Oelen R, Schukking F, de Klein N, et al.
Eur J Hum Genet
. 2023 Feb;
31(11):1300-1308.
PMID: 36807342
Genetic testing in patients with suspected hereditary kidney disease may not reveal the genetic cause for the disorder as potentially pathogenic variants can reside in genes that are not yet...
10.
Oelen R, de Vries D, Brugge H, Gordon M, Vochteloo M, Ye C, et al.
Nat Commun
. 2022 Jun;
13(1):3267.
PMID: 35672358
The host's gene expression and gene regulatory response to pathogen exposure can be influenced by a combination of the host's genetic background, the type of and exposure time to pathogens....