Jonas Kaindl
Overview
Explore the profile of Jonas Kaindl including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
317
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0
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Recent Articles
1.
Vogele M, Zhang B, Kaindl J, Wang L
J Chem Theory Comput
. 2023 Nov;
19(22):8414-8422.
PMID: 37943175
For an effective drug, strong binding to the target protein is a prerequisite, but it is not enough. To produce a particular functional response, drugs need to either block the...
2.
Xu X, Shonberg J, Kaindl J, Clark M, Stossel A, Maul L, et al.
Nat Commun
. 2023 May;
14(1):2992.
PMID: 37225685
No abstract available.
3.
Xu X, Shonberg J, Kaindl J, Clark M, Stossel A, Maul L, et al.
Nat Commun
. 2023 Apr;
14(1):2138.
PMID: 37059717
G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric...
4.
Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, et al.
Angew Chem Int Ed Engl
. 2022 Apr;
61(26):e202200269.
PMID: 35385593
The μ-opioid receptor (μOR) is the major target for opioid analgesics. Activation of μOR initiates signaling through G protein pathways as well as through β-arrestin recruitment. μOR agonists that are...
5.
Uzuneser T, Weiss E, Dahlmanns J, Kalinichenko L, Amato D, Kornhuber J, et al.
J Psychopharmacol
. 2020 Dec;
35(1):65-77.
PMID: 33274688
Background: The therapeutic effects of antipsychotic drugs (APDs) are mainly attributed to their postsynaptic inhibitory functions on the dopamine D2 receptor, which, however, cannot explain the delayed onset of full...
6.
Xu X, Kaindl J, Clark M, Hubner H, Hirata K, Sunahara R, et al.
Cell Res
. 2020 Oct;
31(5):569-579.
PMID: 33093660
Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system. While the hormone epinephrine binds βAR and βAR with similar affinity,...
7.
Klosel I, Schmidt M, Kaindl J, Hubner H, Weikert D, Gmeiner P
ACS Med Chem Lett
. 2020 Jun;
11(6):1316-1323.
PMID: 32551018
Proteinase-activated receptor 2 (PAR2) is a class A G protein-coupled receptor whose activation has been associated with inflammatory diseases and cancer, thus representing a valuable therapeutic target. Pathophysiological roles of...
8.
Liu X, Kaindl J, Korczynska M, Stossel A, Dengler D, Stanek M, et al.
Nat Chem Biol
. 2020 Jun;
16(7):749-755.
PMID: 32483378
Most drugs acting on G-protein-coupled receptors target the orthosteric binding pocket where the native hormone or neurotransmitter binds. There is much interest in finding allosteric ligands for these targets because...
9.
Fischer O, Hofmann J, Rampp H, Kaindl J, Pratsch G, Bartuschat A, et al.
J Med Chem
. 2020 Mar;
63(8):4349-4369.
PMID: 32202101
Muscarinic M receptor antagonists and inverse agonists displaying high affinity and subtype selectivity over the antitarget M are valuable pharmacological tools and may enable improved treatment of chronic obstructive pulmonary...
10.
Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, et al.
Nat Chem Biol
. 2020 Mar;
16(5):507-512.
PMID: 32152538
The α adrenergic receptors (αARs) are G protein-coupled receptors (GPCRs) that respond to adrenaline and noradrenaline and couple to the Gi/o family of G proteins. αARs play important roles in...