Povl Krogsgaard-Larsen
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Explore the profile of Povl Krogsgaard-Larsen including associated specialties, affiliations and a list of published articles.
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65
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690
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Recent Articles
1.
Schousboe A, Wellendorph P, Frolund B, Clausen R, Krogsgaard-Larsen P
Adv Neurobiol
. 2017 Aug;
16:283-296.
PMID: 28828616
Inactivation of GABA-mediated neurotransmission is achieved by high-affinity transporters located at both GABAergic neurons and the surrounding astrocytes. Early studies of the pharmacological properties of neuronal and glial GABA transporters...
2.
Krall J, Balle T, Krogsgaard-Larsen N, Sorensen T, Krogsgaard-Larsen P, Kristiansen U, et al.
Adv Pharmacol
. 2015 Jan;
72:201-27.
PMID: 25600372
A high degree of structural heterogeneity of the GABAA receptors (GABAARs) has been revealed and is reflected in multiple receptor subtypes. The subunit composition of GABAAR subtypes is believed to...
3.
Hoestgaard-Jensen K, Dalby N, Krall J, Hammer H, Krogsgaard-Larsen P, Frolund B, et al.
J Neurosci
. 2014 Dec;
34(49):16256-72.
PMID: 25471566
In the present study, the orthosteric GABAA receptor (GABAAR) ligand 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol (Thio-THIP) was found to possess a highly interesting functional profile at recombinant human GABAARs and native rat GABAARs. Whereas...
4.
Petersen J, Bergmann R, Krogsgaard-Larsen P, Balle T, Frolund B
Neurochem Res
. 2013 Dec;
39(6):1005-15.
PMID: 24362592
The ionotropic GABAA receptors (GABAARs) are widely distributed in the central nervous system where they play essential roles in numerous physiological and pathological processes. A high degree of structural heterogeneity...
5.
Vogensen S, Jorgensen L, Madsen K, Borkar N, Wellendorph P, Skovgaard-Petersen J, et al.
J Med Chem
. 2013 Feb;
56(5):2160-4.
PMID: 23398473
β-Amino acids sharing a lipophilic diaromatic side chain were synthesized and characterized pharmacologically on mouse GABA transporter subtypes mGAT1-4. The parent amino acids were also characterized. Compounds 13a, 13b, and...
6.
Jensen A, Plath N, Pedersen M, Isberg V, Krall J, Wellendorph P, et al.
J Med Chem
. 2013 Jan;
56(3):1211-27.
PMID: 23301527
The isoxazol-3-one tautomer of the bicyclic isoxazole, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol (THAZ), has previously been shown to be a weak GABA(A) and glycine receptor antagonist. In the present study, the potential in this...
7.
Krogsgaard-Larsen P, Thostrup P, Besenbacher F
Angew Chem Int Ed Engl
. 2011 Oct;
50(46):10738-40.
PMID: 21987352
No abstract available.
8.
Madsen K, Ebert B, Clausen R, Krogsgaard-Larsen P, Schousboe A, White H
J Pharmacol Exp Ther
. 2011 Apr;
338(1):214-9.
PMID: 21450931
Modulation of the extracellular levels of GABA via inhibition of the synaptic GABA transporter GAT1 by the clinically effective and selective GAT1 inhibitor tiagabine [(R)-N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid; Gabitril] has proven to...
9.
Frydenvang K, Pickering D, Greenwood J, Krogsgaard-Larsen N, Brehm L, Nielsen B, et al.
J Med Chem
. 2010 Nov;
53(23):8354-61.
PMID: 21067182
We describe an improved synthesis and detailed pharmacological characterization of the conformationally restricted analogue of the naturally occurring nonselective glutamate receptor agonist ibotenic acid (RS)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid (7-HPCA, 5) at AMPA...
10.
Clausen R, Naur P, Kristensen A, Greenwood J, Strange M, Brauner-Osborne H, et al.
J Med Chem
. 2009 Jul;
52(15):4911-22.
PMID: 19588945
The design, synthesis, and pharmacological characterization of a highly potent and selective glutamate GluR5 agonist is reported. (S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (5) is the 8-methyl analogue of (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid ((S)-4-AHCP, 4). Compound...