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Hannah C Feldman

Explore the profile of Hannah C Feldman including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 210
Followers 0
Related Specialties
Biochemistry
Biology
Cell Biology
Top 10 Co-Authors
Dustin J Maly
Feroz R Papa
Bradley J Backes
Rajarshi Ghosh
Rosa Meza-Acevedo
Likun Wang
Morvarid Mehdizadeh
Jeffrey A Bluestone
Benjamin F Cravatt
Shuhei Morita
Published In
ACS Chem Biol
Cell Metab
Nat Chem Biol
Methods Mol Biol
Proc Natl Acad Sci U S A
Affiliations
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Recent Articles
1.
Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviour and drinking in Marchigian Sardinian alcohol-preferring rats
Vozella V, Cruz B, Feldman H, Bullard R, Bianchi P, Natividad L, et al.
Br J Pharmacol . 2023 Jul; 180(24):3130-3145. PMID: 37488777
Background And Purpose: The endocannabinoid (eCB) system plays an important homeostatic role in the regulation of stress circuits and has emerged as a therapeutic target to treat stress disorders and...
2.
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain
Feldman H, Merlini E, Guijas C, DeMeester K, Njomen E, Kozina E, et al.
Proc Natl Acad Sci U S A . 2022 Aug; 119(35):e2208457119. PMID: 35994671
The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon death and is a possible therapeutic target for neurodegenerative...
3.
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
Feldman H, Ghosh R, Auyeung V, Mueller J, Kim J, Potter Z, et al.
Nat Chem Biol . 2021 Sep; 17(11):1148-1156. PMID: 34556859
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate...
4.
Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1
Feldman H, Vidadala V, Potter Z, Papa F, Backes B, Maly D
ACS Chem Biol . 2019 Oct; 14(12):2595-2605. PMID: 31609569
The dual kinase endoribonuclease IRE1 is a master regulator of cell fate decisions in cells experiencing endoplasmic reticulum (ER) stress. In mammalian cells, there are two paralogs of IRE1: IRE1α...
5.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Morita S, Villalta S, Feldman H, Register A, Rosenthal W, Hoffmann-Petersen I, et al.
Cell Metab . 2017 May; 25(5):1207. PMID: 28467938
No abstract available.
6.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Morita S, Villalta S, Feldman H, Register A, Rosenthal W, Hoffmann-Petersen I, et al.
Cell Metab . 2017 Apr; 25(4):883-897.e8. PMID: 28380378
In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases rheostatically...
7.
Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α
Feldman H, Maly D
Methods Mol Biol . 2016 Nov; 1513:233-242. PMID: 27807842
There is an allosteric relationship between the kinase and RNase domains of the ER stress sensor IRE1α. This relationship has been exploited to develop ATP-competitive inhibitors that are able to...
8.
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands
Feldman H, Tong M, Wang L, Meza-Acevedo R, Gobillot T, Lebedev I, et al.
ACS Chem Biol . 2016 May; 11(8):2195-205. PMID: 27227314
The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multidomain protein sensor IRE1α as part of the unfolded protein response (UPR). Clustering of...