Hamish S Sutherland
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Explore the profile of Hamish S Sutherland including associated specialties, affiliations and a list of published articles.
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19
Citations
265
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Recent Articles
11.
Tong A, Choi P, Blaser A, Sutherland H, Tsang S, Guillemont J, et al.
ACS Med Chem Lett
. 2017 Oct;
8(10):1019-1024.
PMID: 29057044
Bedaquiline () is a new drug for tuberculosis and the first of the diarylquinoline class. It demonstrates excellent efficacy against TB but induces phospholipidosis at high doses, has a long...
12.
Palmer B, Sutherland H, Blaser A, Kmentova I, Franzblau S, Wan B, et al.
J Med Chem
. 2015 Mar;
58(7):3036-59.
PMID: 25781074
Novel extended side chain nitroimidazooxazine analogues featuring diverse linker groups between two aryl rings were studied as a potential strategy to improve solubility and oral activity against chronic infection by...
13.
Blaser A, Palmer B, Sutherland H, Kmentova I, Franzblau S, Wan B, et al.
J Med Chem
. 2011 Dec;
55(1):312-26.
PMID: 22148391
Analogues of clinical tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824), in which the OCH(2) linkage was replaced with amide, carbamate, and urea functionality, were investigated as an alternative approach to address oxidative metabolism,...
14.
Sutherland H, Hwang I, Marshall E, Lindsay B, Denny W, Gilchrist C, et al.
Invest New Drugs
. 2011 Sep;
30(5):2035-45.
PMID: 21912889
Purpose: The human tumour suppressor protein p53 is mutated in nearly half of human tumours and most mutant proteins have single amino acid changes. Several drugs including the quinazoline derivative...
15.
Thompson A, Sutherland H, Palmer B, Kmentova I, Blaser A, Franzblau S, et al.
J Med Chem
. 2011 Aug;
54(19):6563-85.
PMID: 21846109
New analogues of antitubercular drug PA-824 were synthesized, featuring alternative side chain ether linkers of varying size and flexibility, seeking drug candidates with enhanced metabolic stability and high efficacy. Both...
16.
Kmentova I, Sutherland H, Palmer B, Blaser A, Franzblau S, Wan B, et al.
J Med Chem
. 2010 Nov;
53(23):8421-39.
PMID: 21069962
New heterocyclic analogues of the potent biphenyl class derived from antitubercular drug PA-824 were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved...
17.
Sutherland H, Blaser A, Kmentova I, Franzblau S, Wan B, Wang Y, et al.
J Med Chem
. 2009 Dec;
53(2):855-66.
PMID: 19968290
Recently described biphenyl analogues of the antituberculosis drug PA-824 displayed improved potencies against M. tuberculosis but were poorly soluble. Heterobiaryl analogues of these, in which the first phenyl ring was...
18.
Palmer B, Thompson A, Sutherland H, Blaser A, Kmentova I, Franzblau S, et al.
J Med Chem
. 2009 Nov;
53(1):282-94.
PMID: 19928920
A series of biphenyl analogues of the new tuberculosis drug PA-824 was prepared, primarily by coupling the known (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol with iodobenzyl halides, followed by Suzuki coupling of these iodides with...
19.
Souza F, Sutherland H, Carlini R, Rodrigo R
J Org Chem
. 2002 Aug;
67(18):6568-70.
PMID: 12201786
Several enones are converted into their alpha-iodo derivatives in excellent yields and carbonylated with palladium catalysis in the presence of alcohol or amines to the alpha-carbonyl enones in satisfactory yields.