H van Steeg
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Explore the profile of H van Steeg including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
1440
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Recent Articles
11.
Brash D, Wikonkal N, Remenyik E, van der Horst G, Friedberg E, Cheo D, et al.
J Invest Dermatol
. 2001 Nov;
117(5):1234-40.
PMID: 11710938
The stratum corneum and DNA repair do not completely protect keratinocytes from ultraviolet B. A third defense prevents cells with DNA photoproducts from becoming precancerous mutant cells: apoptosis of ultraviolet-damaged...
12.
van Kreijl C, McAnulty P, Beems R, VYNCKIER A, van Steeg H, Fransson-Steen R, et al.
Toxicol Pathol
. 2001 Nov;
29 Suppl:117-27.
PMID: 11695547
DNA repair deficient Xpa-/- and Xpa-/-/p53+/- knock-out mice in a C57BL/6 genetic background, referred to as respectively the XPA and XPA/p53 model, were investigated in the international collaborative research program...
13.
van Steeg H, De Vries A, van Oostrom CTh , van Benthem J, Beems R, van Kreijl C
Toxicol Pathol
. 2001 Nov;
29 Suppl:109-16.
PMID: 11695546
Xeroderma pigmentosum (XP) is a rare autosomal recessive disease in which repair of ultraviolet (UV)-induced DNA damage is impaired or is totally absent due to mutations in genes controlling the...
14.
Boonstra A, van Oudenaren A, Baert M, van Steeg H, Leenen P, van der Horst G, et al.
J Invest Dermatol
. 2001 Jul;
117(1):141-6.
PMID: 11442761
Ultraviolet B irradiation has serious consequences for cellular immunity and can suppress the rejection of skin tumors and the resistance to infectious diseases. DNA damage plays a crucial role in...
15.
van Steeg H
Toxicol Lett
. 2001 Apr;
120(1-3):209-19.
PMID: 11323179
Xpa mice, which have a completely defective nucleotide excision repair (NER) pathway, have a cancer predisposition when exposed to several carcinogens. NER is one of the major DNA repair pathways...
16.
Klein J, Beems R, Zwart P, Hamzink M, Zomer G, van Steeg H, et al.
Carcinogenesis
. 2001 Apr;
22(4):619-26.
PMID: 11285198
The effects of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in DNA repair deficient XPA(-/-) mice. The nullizygous XPA-knockout mice, which lack a functional nucleotide excision repair (NER) pathway, were...
17.
Rebel H, Mosnier L, Berg R, van Steeg H, van Kranen H, de Gruijl F
Cancer Res
. 2001 Feb;
61(3):977-83.
PMID: 11221893
p53 mutations appear to be early events in skin carcinogenesis induced by chronic UVB irradiation. Clusters of epidermal cells that express p53 in mutant conformation ("p53 positive foci") are easily...
18.
Wijnhoven S, Kool H, van Oostrom C, Beems R, Mullenders L, van Zeeland A, et al.
Cancer Res
. 2000 Nov;
60(20):5681-7.
PMID: 11059760
Cockayne syndrome (CS) patients are deficient in the transcription coupled repair (TCR) subpathway of nucleotide excision repair (NER) but in contrast to xeroderma pigmentosum patients, who have a defect in...
19.
Wijnhoven S, Kool H, Mullenders L, van Zeeland A, Friedberg E, van der Horst G, et al.
Oncogene
. 2000 Oct;
19(43):5034-7.
PMID: 11042691
DNA damages caused by cellular metabolites and environmental agents induce mutations, that may predispose to cancer. Nucleotide excision repair (NER) is a major cellular defence mechanism acting on a variety...
20.
van Oosten M, Rebel H, Friedberg E, van Steeg H, van der Horst G, van Kranen H, et al.
Proc Natl Acad Sci U S A
. 2000 Sep;
97(21):11268-73.
PMID: 11005836
Nucleotide excision repair (NER), apoptosis, and cell-cycle regulation are major defense mechanisms against the carcinogenic effects of UVB light. NER eliminates UVB-induced DNA photolesions via two subpathways: global genome repair...