C T van Oostrom
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Explore the profile of C T van Oostrom including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
345
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Recent Articles
1.
Jongbloed F, Saat T, Verweij M, Payan-Gomez C, Hoeijmakers J, van den Engel S, et al.
Sci Rep
. 2017 Jan;
7:40901.
PMID: 28102354
During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this...
2.
Vermeij W, Dolle M, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri C, et al.
Nature
. 2016 Aug;
537(7620):427-431.
PMID: 27556946
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth...
3.
Wijnhoven S, Kool H, van Oostrom C, Beems R, Mullenders L, van Zeeland A, et al.
Cancer Res
. 2000 Nov;
60(20):5681-7.
PMID: 11059760
Cockayne syndrome (CS) patients are deficient in the transcription coupled repair (TCR) subpathway of nucleotide excision repair (NER) but in contrast to xeroderma pigmentosum patients, who have a defect in...
4.
van Oostrom C, Boeve M, van den Berg J, De Vries A, Dolle M, Beems R, et al.
Environ Mol Mutagen
. 1999 Oct;
34(2-3):124-30.
PMID: 10529736
XPA-deficient mice have a complete deficiency in nucleotide excision repair, and as such they display a cancer predisposition after exposure to several carcinogens. Besides being sensitive to genotoxic agents applied...
5.
Bol S, van Steeg H, van Oostrom C, TATES A, Vrieling H, de Groot A, et al.
Mutagenesis
. 1999 Jun;
14(3):317-22.
PMID: 10374999
The butylating agent N-n-butyl-N-nitrosourea (BNU) was employed to study the role of nucleotide excision repair (NER) in protecting mammalian cells against the genotoxic effects of monofunctional alkylating agents. The direct...
6.
De Vries A, van Oostrom C, Dortant P, Beems R, van Kreijl C, Capel P, et al.
Mol Carcinog
. 1997 May;
19(1):46-53.
PMID: 9180928
Defects in the xeroderma pigmentosum complementation group A-correcting (XPA) gene, which encodes a component of the nucleotide excision repair (NER) pathway, are associated with the cancer-prone human disease xeroderma pigmentosum....
7.
Kroese E, Dortant P, van Steeg H, van Oostrom C, van der Houven van Oordt C, van Kranen H, et al.
Carcinogenesis
. 1997 May;
18(5):975-80.
PMID: 9163683
E mu-pim-1 transgenic mice are predisposed to develop lymphomas. Due to their low spontaneous tumour incidence and their increased sensitivity towards the lymphomagen ethylnitrosourea these mice may present an interesting...
8.
De Vries A, van Oostrom C, Hofhuis F, Dortant P, Berg R, de Gruijl F, et al.
Nature
. 1995 Sep;
377(6545):169-73.
PMID: 7675086
Xeroderma pigmentosum patients with a defect in the nucleotide-excision repair gene XPA are characterized by, for example, a > 1,000-fold higher risk of developing sunlight-induced skin cancer. Nucleotide-excision repair (NER)...
9.
van Oostrom C, De Vries A, Verbeek S, van Kreijl C, van Steeg H
Nucleic Acids Res
. 1994 Jan;
22(1):11-4.
PMID: 8127648
Xeroderma Pigmentosum is a human disease, which is, among others, characterized by a high incidence of (sunlight induced) skin cancer, due to a defect in nucleotide excision repair (NER). The...
10.
van Steeg H, van Oostrom C, Hodemaekers H, Peters L, Thomas A
Biochem J
. 1991 Mar;
274 ( Pt 2):521-6.
PMID: 2006916
The enzyme ornithine decarboxylase (ODC, EC 4.1.1.17) is believed to play an essential role in the growth and differentiation of cells by regulating the biosynthesis of polyamines. The 5' untranslated...